introduction: multiple sclerosis (ms) is a chronic inflammatory demyelinating disease. in the present study, we investigated the response of subventricular zone (svz) adult stem cells in the experimental autoimmune encephalomyelitis (eae), an animal model of ms, and also the differentiation fate of these stem cells. methods: mice were immunized with mog peptide emulsified in complete freund&apo...

Introduction: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease. In the present study, we investigated the response of subventricular zone (SVZ) adult stem cells in the experimental autoimmune encephalomyelitis (EAE), an animal model of MS, and also the differentiation fate of these stem cells. Methods: Mice were immunized with MOG peptide emulsified in complete Freund'...

Introduction: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease. In the present study, we investigated the response of subventricular zone (SVZ) adult stem cells in the experimental autoimmune encephalomyelitis (EAE), an animal model of MS, and also the differentiation fate of these stem cells. Methods: Mice were immunized with MOG peptide emulsified in complete Freund's a...

Experimental autoimmune encephalomyelitis (EAE) is one of the best-documented animal models of autoimmune disease. We examined the role of CD8+CD122+ regulatory T cells, which we previously identified as naturally occurring regulatory T cells that effectively regulate CD8+ T cells, in EAE. Depletion of CD8+CD122+ regulatory T cells by in vivo administration of anti-CD122 mAb resulted in persist...

introduction: multiple sclerosis (ms) is a progressive and autoimmune neurodegenerative disease of the central nervous system (cns). this disease is renowned through symptoms like inflammation, demyelination and the damage of neurological actions. melittin is one of components of bee venom and has anti-neuroinflammatory effects. curcumin also, a dietary spice from turmeric, has outstanding anti...

Multiple Sclerosis (MS) is an autoimmune disease, which is characterized by demyelination and neuroinflammation. Extracellular Matrix (ECM) have important role in the central nervous system (CNS). Alterations are happening to the ECM after the CNS disorder like MS, Alzheimer and other neural injury. Tenasin-C (TnC) is a glycoprotein that is highly expressed in inflammatory conditions of the CNS...

objective(s):experimental allergic encephalomyelitis (eae) is an autoimmune disease validated as animal model of multiple sclerosis (ms). administration of genistein, a phytoestrogenic component of soy, to mice at the onset of eae is known to attenuate the clinical signs of the disease. the potential effects of genistein on established eae is less studied. in the current study, we aimed to comp...