F2-isoprostanes (F2-IsoPs) are a gold marker of lipid peroxidation in vivo, whereas F4-neuroprostanes (F4-NPs) measured in cerebrospinal fluid (CSF) or brain tissue selectively indicate neuronal oxidative damage. Gas chromatography/negative-ion chemical-ionization mass spectrometry (GC/NICI-MS) is the most sensitive and robust method for quantifying these compounds, which is essential for CSF s...

OBJECTIVE The relations between acoustic measures and their articulatory bases have rarely been tested in dysarthria but are important for diagnostic and treatment purposes. We tested the association between acoustic measures of F2 range and F2 slope with kinematic measures of tongue movement displacement and speed in individuals with amyotrophic lateral sclerosis (ALS) and healthy controls spe...

An adverse environment in early life is often associated with dysregulation of the hypothalamo-pituitary-adrenal (HPA) axis and higher rates of mood disorders in adulthood. In rats, exposure to social stress during pregnancy results in hyperactive HPA axis responses to stress in the adult offspring and heightened anxiety behavior in the males, but not the females. Here we tested whether, withou...

In the presence of F2 overpressure, at elevated temperature, and despite similarity their crystal structures, CuF2 AgF2 unexpectedly form two distinct solid solutions, (Cu1−xAgx)F2 (Ag1−xCux)F2. Each phase shows different mutual solubility Cu2+ Ag2+ (shown as yellow violet balls), magnetic properties are strongly impacted by this seemingly simple isoelectronic substitution. More information can...

Daun sirsak (Annona muricata L.) mengandung flavonoid yang memiliki aktivitas antioksidan sangat kuat . Telah dibuat formula handbody lotion daun masing-masing 0,05% (F1), 0,1% (F2), 0,15% (F3). Tujuan penelitian ini untuk melihat dari ketiga ekstrak etanol (F1, F2, F3) telah dibuat.Uji dilakukan terhadap F1, dan F3 menggunakan metode DPPH dengan menentukan nilai IC 50 formula. Hasil menunjukka...

DEFINITION 0.1. Let Fx, F2, F be subsets of a boolean algebra B. Then the (F1, F2, F)-Separation Principle, written Sep(F~, F2, F) for short, is the following: whenever aEF1, bEF2 and a ^ b = O , there is c~F with a<.c and cAb=O. The (F1, F2, F)-Interpolation Principle, written Int(Ft , F2, F) for short, is the following: whenever a~F1, b~F2 and a<.b there is ceF such that a<~c<~b. Clearly Int ...

During a follicular wave in mares, the two largest follicles (F1 and F2) begin to deviate in diameter when F1 is a mean of 22.5 mm. The intrafollicular effects of pregnancy-associated plasma protein-A (PAPP-A), IGF-I, activin-A and vascular endothelial growth factor (VEGF) on other follicular-fluid factors during deviation were studied. In four treated groups (n = 7/group), a single dose of one...

Unlike previous pandemic viruses, the 2009 H1N1 pandemic influenza virus does not code for the virulence factor PB1-F2. The genome of the 2009 H1N1 virus contains three stop codons preventing PB1-F2 expression; however, PB1-F2 production could occur following genetic mutation or reassortment. Thus, it is of great interest to understand the impact that expression of the PB1-F2 protein might have...

BACKGROUND The malaria parasite Plasmodium falciparum EBA-175 binds its receptor sialic acids on glycophorin A when invading erythrocytes. The receptor-binding region (RII) contains two cysteine-rich domains with similar cysteine motifs (F1 and F2). Functional relationships between F1 and F2 domains and characterization of EBA-175 were studied using specific monoclonal antibodies (mAbs) against...