The gene networks underlying closure of the optic fissure during vertebrate eye development are poorly understood. Here, we profile global gene expression during optic fissure closure using laser capture microdissected (LCM) tissue from the margins of the fissure. From these data, we identify a unique role for the C(2)H(2) zinc finger proteins Nlz1 and Nlz2 in normal fissure closure. Gene knock...

BACKGROUND Multi-detector Computed Tomography has become an invaluable tool for the diagnosis of chronic respiratory diseases. Based on CT images, the automatic algorithm to detect the fissures and divide the lung into five lobes will help regionally quantify, amongst others, the lung density, texture, airway and, blood vessel structures, ventilation and perfusion. METHODS Sagittal adaptive f...

This description is mainly based on experience gained at Great Ormond Street over the past nine years-about 300 cases having been admitted. It owes much to the teaching of Denis Browne. The classification of Ladd and Gross (I934) into four types has been abandoned because it did not seem to give useful grouping of cases with similar origins, treatment or prognosis. A classification has been dev...

The azygos fissure is typically visible on chest radiography as a right paramediastinal supernumerary line in projection of the right lung apex. The azygos vein, located at the bottom of the fissure, is visible as a teardrop-shaped opacity. The empty azygos fissure is a rare finding. It is the consequence of the displacement of the azygos vein out of the fissure with a close paramediastinal pos...

The motor unit fibre density in the external anal sphincter muscle has been measured in 13 normal subjects aged 18 to 78 years, and in 14 patients with ano-rectal incontinence, aged 17 to 72 years. The mean fibre density in the normal subjects was 1.5 +/- 0.16, and in the incontinent subjects it was 2.17 +/- 0.28 (p less than 0.001). These findings provide support for the suggestion that ano-re...

A case in which an infiltrating mucinous carcinoma developed within a suprasphincteric fistula-in-ano is presented. The diagnosis was suspected on biopsy and confirmed by repeat biopsy. The clinical and histological features of this case establish with certainty that the carcinoma arose within the fistula and was not a secondary manifestation of the tumour. It is suggested that this rare compli...

We describe a new potential function based proof for anO(log k)-competitive algorithm for weighted paging, and more generally anO(log k/(k−h+1))-competitive algorithm for the weighted (h, k)-paging problem. In contrast to previous results that are based on the online primal-dual framework, our analysis is extremely simple, and we believe that the technique might be useful in the analysis of oth...

statement of the problem: fissure sealant therapy is among the most effective methods of preventing dental caries. however, it is lengthy and isolation of the teeth is difficult in this procedure especially in young children. using new hydrophilic fissure sealant may reduce such problems. purpose: this study aimed to evaluate the clinical success of a hydrophilic fissure sealant on the lower pe...