A prolonged expansion of GGGGCC repeat within non-coding region of C9orf72 gene has been identified as the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which are devastating neurodegenerative disorders. Formation of unusual secondary structures within expanded GGGGCC repeat, including DNA and RNA G-quadruplexes and R-loops was proposed to ...

the objective of the present study was to determine the grades of nonspecific bacterial infection of genitalia of repeat breeding cattle by a simple and rapid test under field condition. for this purpose, a total of 100 crossbred jersey cows comprising of 80 repeat breeding animals presented for treatment and 20 normal cyclic (control group) animals presented for artificial insemination at thei...

bovine genital campylobacteriosis is one of the most economically important diseases of dairy cattleresulting in lowered fertility, embryo mortality and abortion, repeated returns to service, reduced pregnancyrates and extended calving intervals. while the occurrence of repeat breeding syndrome and abortions arereported from many iranian dairy cattle farms, little information is available regar...

mutations of the androgen receptor (ar) gene give rise to a wide array of phenotypic abnormalities. various mutations of the ar gene and expanded polyglutamine repeats (cag) at exon 1 of the gene have been reported in patients with infertility and neurodegenerative diseases. however, the role of the ar gene trinucleotides repeats has not been systemically studied in those with hypospadias or ge...

COVID-19 pandemic-related pressures on primary care may have driven the inappropriate continuation of antibiotic prescriptions. Yet, prescribing modality (repeat/non-repeat) has not previously been investigated in a pandemic context. With approval NHS England, we conducted retrospective cohort study >19 million English patient records using OpenSAFELY-TPP analytics platform. We analysed repe...

Between three and six tri- and tetranucleotide repeat microsatellite loci were analyzed in 3720 samples collected from four different species of baleen whales. Ten of the 18 species/locus combinations had imperfect allele arrays, i.e., some alleles differed in length by other than simple integer multiples of the basic repeat length. The estimate of the average number of alleles and heterozygosi...