Abstract Genetic engineering of T-cells using chimeric antigen receptors (CARs) has shown promise in the treatment relapsed/refractory B-cell leukemia. However, a significant percentage patients will eventually relapse, often due to emergence tumor cells expressing low levels target antigen. Previous research demonstrated that hinge domain CAR plays crucial role regulating cytotoxic capabilitie...

Oscillating micro-cantilever array enables immunoassay for single-step label-free analysis of candidate malaria vaccines. Differential read-out reveals epitope-specific timeline infection in complex serum samples.

This study was carried out at Sakha Animal Production Research Station, during the period from Oct., 2009 to Sept., 2010. Forty Rahmani ewes were divided into three treatment groups: the 1st, 2nd and 3rd treatment groups were intramuscularly injected (Day 0) with 1 mL GnRH analogue followed by an intramuscular injection with 0.7 mL PGF2α5 (G1), 6 (G2) or 7 (G3) days later. A second dose of 1 mL...

Abstract COVID-19 and SARS-CoV-2 variants continue to threaten human health life worldwide. Thousands of structures related have been rapidly determined, either by X-ray crystallography or CryoEM deposited in the Protein Data Bank (PDB) since 2020. Here, we systematically investigated 302 antibodies 78 nanobodies complex with spike protein receptor binding domain (RBD) SARS-CoV-2. We identified...

Compositions of biotite from three different rock types of Mashhad granitoids, i.e., granodiorite, monzogranite and leucogranite in NE of Iran have been documented by electron microprobe and wet chemistry for Fe3+ and Fe2+. Mashhad granitoids have been geochronologically and petrologically grouped into G1 and G2 phases. Microprobe data show that the total Fe contents in biotite from G2 leucogra...

The study was conducted on 90 serum samples of people with prostate diseases (G1-include 24 for patients cancer-PC , G2- include benign prostatic hyperplasia-BPH and 22 prostatitis G3), compared 20 healthy individuals as control group. Prostate-specific antigen-PSA, human kallikrein-2-hK2, fibrinogen gamma-FGG, total anti-oxidant capacity-TAC, Vitamin D3-VD3. results showed that the activity PS...