We have calculated the dose enhancements close to metal implants in Gamma Knife radiosurgery using different beam sizes, i.e., 4, 8 and 18 mm collimator helmets sin addition to the previous calculations using the 14 mm collimator helmetd. For the 8 and 18 mm helmets, the obtained results were similar to those obtained using the 14 mm helmet, which can be explained by the similar beam profiles w...

OBJECTIVE Gamma Knife® (GK) (Elekta Instruments, Stockholm, Sweden) radiosurgery is well established for treatment of brain metastases. There are limited data on patients treated with GK from gynecological cancers. The authors sought to determine the effectiveness of the GK in patients with brain metastases from gynecological cancers. METHODS An IRB-approved database was queried for patients ...

The accuracy of the dose planning system (Leksell GammaPlan), used in Gamma Knife (type B) radiosurgery at extreme irradiation depths, was verified using the Monte Carlo technique. EGS4 Monte Carlo calculations were employed to calculate the dose distribution along the x, y and z axes for an irradiation relatively shallow in a spherical bony cavity water phantom. Two different sizes of the coll...

A melanoma patient with brain metastases was treated by gamma-knife radiosurgery and immunotherapy with autologous tumor-lysate-loaded dendritic cells (DC). Ten years after the combined treatment, the patient remains in complete remission. Remarkable immunologic correlates to the clinical development were the transient induction of NY-ESO-1 antibody and the durable expansion of MAGE-A1p161-169 ...

BACKGROUND The changing trends in the management of vestibular schwannoma (VS) in our practice over the last two decades as well as the current status are presented here. MATERIALS AND METHODS The observations are based on the experience of 559 consecutive cases of VS operated by the first author between 1987 and 2008, 438 of which were operated by microsurgery and 139 by gamma knife radiosur...

Introduction: Stereotactic radiosurgery (SRS) is one of the conformal radiotherapy methods and Gamma Knife is a non-invasive SRS technique to treat intracranial lesions with 201 Co- 60 sources without need to surgery and bleeding. Beam penumbra phenomenon leads to irradiation outside the field and normal tissues. Therefore, considering it is momentous to attain the acceptable t...

nelson’s syndrome nowadays a rare entity results from an adrenocorticotropin (acth)–secreting pituitary adenoma in patients with refractory cushing's disease after a therapeutic bilateral adrenal gland removal. we report a case of 25 year old female with cushing’s disease who was initially managed with medical treatment, but in view of severe persistent hyper cortisol state was subjected t...

Many patients with mesial temporal lobe epilepsy continue to have seizures despite medical therapy. For these patients, one recourse is surgical resection of the mesial temporal lobe, with its attendant risks. Noninvasive treatment with Gamma Knife radiosurgery is under active investigation as a possible alternative to open surgery. Accumulated evidence from multiple studies shows radiosurgery ...