Top-gated silicon nanowire transistors are fabricated by preparing all terminals (source, drain, and gate) on top of the nanowire in a single step via dose-modulated e-beam lithography. This outperforms other time-consuming approaches requiring alignment of multiple patterns, where alignment tolerances impose a limit on device scaling. We use as gate dielectric the 10-15 nm SiO(2) shell natural...

Introduction: Asymptomatic diabetic patients are at increased risk of cardiovascular complications. Myocardial perfusion scan may be effective in risk evaluation in this population. Methods: 106 asymptomatic diabetic patients (age: min: 37, max: 82, mean: 57.73±8.88), including 56 females (52.8%) and 50 males (47.2%) were enrolled in the study. Myocardial perfusion scintigraphy was performed b...

PURPOSE The sense of vision in humans is robust, and visual flickering is rarely experienced. To investigate this mechanism, electrophysiological and molecular biological techniques were used on human cone and rod photoreceptors. METHODS Voltage-gated currents were recorded using the patch-clamp technique on isolated human cones, and especially their voltage-gated Na+ currents were analyzed i...

BACKGROUND Asymptomatic patients with severe coronary atherosclerosis may have a normal resting electrocardiogram and stress test. AIM To assess the yield of Gated Single Photon Emission Computer Tomography (SPECT) for the screening of silent myocardial ischemia in type 2 diabetic patients. MATERIAL AND METHODS Electrocardiogram, stress test and gated-SPECT were performed on 102 type 2 diab...

An in silico search strategy was developed to identify potential voltage-sensing domains (VSD) for the development of genetically encoded voltage indicators (GEVIs). Using a conserved charge distribution in the S2 α-helix, a single in silico search yielded most voltage-sensing proteins including voltage-gated potassium channels, voltage-gated calcium channels, voltage-gated sodium channels, vol...

Background: Real cardiac phantoms are often used to assess the performance of software for gated single-photon emission computed tomography(SPECT). However, these phantoms have disadvantages in that they are not very similar to actual hearts and setting a perfusion defect is not easy. To overcome these problems, we developed a digital myocardial phantom, named%Myo-Simu'. The aims of this study ...

Background: Excitotoxicity is a common pathological process in neurodegenerative diseases associated with overactivity of N-methyl-D-aspartate (NMDA) and P/Q type voltage-gated calcium (Cav2.1) channels. Omega-lycotoxin-Gsp2671g is a therapeutic tool to modulate overactive Cav2.1 (P/Q type) channels. Omega-lycotoxin binds to Cav2.1 channels with high affinity and selectivity. This study aimed t...

When incorporated into a top-hat electrostatic analyzer, gate electrode enables the separation of ions by their mass-per-charge with modest mass resolution (M/∆M ∼ 10). Gated-time-of-flight (TOF) instruments avoid energy straggling and angular scattering effects prevalent in foil-based detection systems, providing more pristine measurements three-dimensional distribution functions incident ions...

Electrolyte-gated organic transistors (EGOTs) are promising and versatile devices for next-generation biosensors, neuromorphic systems, low-voltage electronics. They particularly indicated applications where stable operation in aqueous environment cost-effective manufacturing required. Indeed, EGOTs can be fabricated through low-cost, large area, scalable techniques, such as printing, from a po...

ABSTRACT The behavior of ion channels and transporters is often modeled using discrete state continuous-time Markov models. Such models are helpful for the interpretation experimental data can guide design experiments by testing specific predictions. Here, we describe a computational tool that allows us to create chosen complexity calculate predictions on macroscopic scale, as well single-molec...