BACKGROUND Plasma creatinine concentration and calculated creatinine clearance are of limited value as glomerular filtration rate (GFR) markers in patients with decompensated liver cirrhosis. We assessed plasma cystatin C as an indicator of GFR in such patients. METHODS We studied 36 patients with decompensated liver cirrhosis and 56 noncirrhotic controls, both groups including individuals wi...

CKD could be simplified classified in two major groups: diabetic and nondiabetic chronic kidney disease. (Table 11.1.) (2). The diagnosis of CKD is based on level of glomerular filtration rate (GFR) and by some of the markers of kidney damage. Differential diagnosis of CKD is based on the history, physical examination and laboratory evaluation. Proteinuria is the principal marker of kidney dama...

Balkan endemic nephropathy (BEN) is chronic tubulointersticial nephritis of unknown aetiology characterized by an insidious onset and gradual progression to end stage renal disease (ESRD). Endemic regions of Bosnia and Herzegovina are Posavina and Semberija, sited at basin of Sava River. In BEN, just like in other chronic renal diseases (CKD), glomerular filtration rate (GFR), is assumed a mark...

conclusions: these findings suggested that plasma adpn level is inversely associated with gfr and directly correlate with hdl-cholesterol and inversely with some, but not all metabolic factors of ckd patients who were not undergone dialysis. results: plasma adpn level was significantly higher in ckd patients than control group (p = 0.04). it was directly correlated with hdl-cholesterol (r = 0.5...

RATIONALE AND OBJECTIVES To investigate in a unilaterally nephrectomized porcine model whether gadolinium contrast media (Gd-CM) are less nephrotoxic than iodine media (I-CM) in x-ray arteriography of a kidney made temporarily ischemic by arterial balloon occlusion. MATERIALS AND METHODS In a noncrossover design, 3 mL of each test solution were injected in eight pigs (mean weight 19 kg) at a ...

4 ORIGINAL PAPERS 5 ABBREVIATIONS 6 INTRODUCTION 7 Marker substances for GFR 8 Endogenous markers 8 Exogenous markers 8 Clearance techniques for determination of GFR 9 Continuous infusion method 9 Single injection method 10 Single injection, single sample methods 12 AIMS OF THE STUDY 16 MATERIALS AND METHODS 17 Materials 17 Cr-EDTA and Tc-DTPA analysis 18 Iohexol analysis 19 Derivation of a sin...

Determination of glomerular filtration rate (GFR) in conscious mice is cumbersome for the experimenter and stressful for the animals. Here we report on a simple new technique allowing the transcutaneous measurement of GFR in conscious mice. This approach extends our previously developed technique for rats to mice. The technique relies on a miniaturized device equipped with an internal memory th...

Endogenous markers of kidney function are insensitive to early declines in glomerular filtration rate (GFR) and in rodent models, validated, practical alternatives are unavailable. In this study, we determined GFR by modeling the plasma clearance of two compounds, iohexol and inulin, and compared the findings to common endogenous markers. All plasma clearance methods of both iohexol and inulin ...