Context: Several metrics have been proposed to measure the extent to which class members are related. Connectivity-based class cohesion metrics measure the degree of connectivity among the class members. Objective: We propose a new class cohesion metric that has higher discriminative power than any of the existing cohesion metrics. In addition, we empirically compare the connectivity and non-co...

Sister chromatid cohesion mediated by the cohesin complex is essential for chromosome segregation in mitosis and meiosis [1]. Rec8-containing cohesin, bound to Smc3/Smc1α or Smc3/Smc1β, maintains bivalent cohesion in mammalian meiosis [2-6]. In females, meiotic DNA replication and recombination occur in fetal oocytes. After birth, oocytes arrest at the prolonged dictyate stage until recruited t...

Cohesion has been a topic of interest since structured design [20, 23] in the 1970’s. Today, there are numerous researchers continuing this work into object-oriented designs [1, 3, 5, 7, 9, 10, 12, 13, 16, 18, 19, 22]. Most of the current research has focused on the interaction of methods within a class, the inter-method cohesion. In this paper we consider both the inter-method cohesion and the...

Cohesin complex mediates cohesion between sister chromatids, which promotes high-fidelity chromosome segregation. Eco1p acetylates the cohesin subunit Smc3p during S phase to establish cohesion. The current model posits that this Eco1p-mediated acetylation promotes establishment by abrogating the ability of Wpl1p to destabilize cohesin binding to chromosomes. Here we present data from budding y...

Cohesins are required both for the tethering together of sister chromatids (termed cohesion) and subsequent condensation into discrete structures-processes fundamental for faithful chromosome segregation into daughter cells. Differentiating between cohesin roles in cohesion and condensation would provide an important advance in studying chromatin metabolism. Pds5 is a cohesin-associated factor ...

This paper presents a method for automatically recognizing local cohesion between utterances, which is one of the discourse structures in task-oriented spoken dialogues. More specifically we can automatically acquire discourse knowledge from an annotated corpus with local cohesion. In this paper we focus on speech act type-based local cohesion. The presented method consists of two steps 1) iden...

INTRODUCTION The concept of social cohesion has invoked debate due to the vagueness of its definition and the limitations of current measurements. This paper attempts to examine the concept of social cohesion, develop measurements, and investigate the relationship between social cohesion and individual health. METHODS This study used a multilevel study design. The individual-level samples fro...

Genome integrity depends on correct chromosome segregation, which in turn relies on cohesion between sister chromatids from S phase until anaphase. S phase cohesion, together with DNA double-strand break (DSB) recruitment of cohesin and formation of damage-induced (DI) cohesion, has previously been shown to be required also for efficient postreplicative DSB repair. The budding yeast acetyltrans...

Sister chromatid cohesion is essential for chromosome segregation and is mediated by cohesin bound to DNA. Cohesin-DNA interactions can be reversed by the cohesion-associated protein Wapl, whereas a stably DNA-bound form of cohesin is thought to mediate cohesion. In vertebrates, Sororin is essential for cohesion and stable cohesin-DNA interactions, but how Sororin performs these functions is un...