The absence of a functional ATP Binding Cassette (ABC) protein called the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) from apical membranes of epithelial cells is responsible for cystic fibrosis (CF). Over 90% of CF patients carry at least one mutant allele with deletion of phenylalanine at position 508 located in the N-terminal nucleotide binding domain (NBD1). Biochemical and c...

A total of 110 Escherichia coli strains of serogroup O119 were examined for the presence of virulence properties characteristic of enteropathogenic E. coli (EPEC). Three virulence patterns were distinguished based on the detection of a chromosomal gene mediating intimate attachment (eaeA) and plasmid DNA involved in localized adherence (EAF and bfpA). The first pattern, represented by strains w...

Objectives Anti-citrullinated peptides antibodies (ACPAs) have high specificity for the diagnosis of rheumatoid arthritis (RA), but their role in the pathophysiology is not fully established. The main genetic risk factor for RA, the shared epitope in major histocompatibility complex class II, is associated with ACPAs. Among certain non-human primates, 8% carry the shared epitope called H6 haplo...

We demonstrate the generation of high-brightness supercontinuum inside thuliumdoped fiber amplifier in 1950-2450nm spectral range with 1.7W output power and 32% slope efficiency, seeded by tunable 2000nm mode-locked laser and assisted by H4-H5/F4-H6 thulium transitions. OCIS codes: (320.6629) Supercontinuum generation; (160.5690) Rare-earth-doped materials; (060.4370) Nonlinear optics, fibers

Abstract Histidine-rich peptides confer self-assembling properties to recombinant proteins through the supramolecular coordination with divalent cations. This fact allows cost-effective, large-scale generation of microscopic and macroscopic protein materials intriguing biomedical properties. Among such materials, resulting from simple bioproduction building blocks, homomeric nanoparticles are s...