نتایج جستجو برای: h6

تعداد نتایج: 874  

Journal: :Micromachines 2011
Narender Rana Christopher Kossow Eric T. Eisenbraun Robert E. Geer Alain E. Kaloyeros

The relative adhesion of two genetically engineered polypeptides termed as H6-(YEHK)x21-H6 and C6-(YEHK)X21-H6 has been investigated following growth and self-assembly on highly oriented pyrolytic graphite (HOPG), SiO2, Ni, and Au substrates to study covalent surface attachment via histidine (H) and cysteine (C) groups incorporated in the polypeptides. Both polypeptides formed predominantly bil...

2016
Jian-gui Guo Cheng-cheng Guo Zhen-qiang He Zhi-gang Liu Yang Wang Yong-gao Mou

Currently, immunotherapy by blocking the immune checkpoint inhibitors, such as anti-PD-1, has been carried out in many clinical studies on recurrent glioma, and the preliminary results are satisfactory, which provides a rationale for the exploration of immune checkpoint inhibitors in glioma. B7-H6 is a newly discovered member of the B7 family, which triggers antitumor of natural killer cell cyt...

Journal: :Blood 2013
Jessica Matta Myriam Baratin Laurent Chiche Jean-Marie Forel Céline Cognet Guillemette Thomas Catherine Farnarier Christelle Piperoglou Laurent Papazian Damien Chaussabel Sophie Ugolini Frédéric Vély Eric Vivier

B7-H6, a member of the B7 family of immunoreceptors, is as a cell-surface ligand for the NKp30-activating receptor expressed on natural killer cells. B7-H6 is not detected in normal human tissues at steady state but is expressed on tumor cells. However, whether B7-H6 can be expressed in other conditions remains unknown. We analyzed here the pathways that lead to the expression of B7-H6 in nontr...

Journal: :Journal of immunology 2012
Christian Kellner Tina Maurer Daniela Hallack Roland Repp Jan G J van de Winkel Paul W H I Parren Thomas Valerius Andreas Humpe Martin Gramatzki Matthias Peipp

Induced self expression of the NKp30 ligand B7-H6 facilitates NK cell-mediated elimination of stressed cells. A fusion protein consisting of the ectodomain of B7-H6 and the CD20 single-chain fragment variable 7D8 was generated to mimic an induced self phenotype required for NK cell-mediated target cell elimination. B7-H6:7D8 had bifunctional properties as reflected by its ability to simultaneou...

2015
Jacek Mackiewicz Marek Kotlarski Ewelina Dondajewska Anita Nowicka-Kotlarska Łukasz Krokowicz Urszula Kazimierczak

BACKGROUND Cell based vaccines encoding Hyper-IL-6 (H6) and Hyper-IL-11 (H11) present high activity in murine melanoma and renal cancer model. We evaluated the efficacy of cellular vaccines modified with H6 or H11 combined with cyclophosphamide in orthotopic murine prostate cancer model. MATERIAL AND METHODS TRAMP cells were transduced with H6 and H11 cDNA (TRAMP-H6 and TRAMP-H11). An orthoto...

2015
Fengyun Ni Elena Kondrashkina Qinghua Wang Toru Takimoto

In June 2013, the first human infection by avian influenza A(H6N1) virus was reported in Taiwan. This incident raised the concern for possible human epidemics and pandemics from H6 viruses. In this study, we performed structural and functional investigation on the hemagglutinin (HA) proteins of the human-infecting A/Taiwan/2/2013(H6N1) (TW H6) virus and an avian A/chicken/Guangdong/S1311/2010(H...

Journal: :Chemical communications 2017
Luke C Delmas Peter N Horton Andrew J P White Simon J Coles Paul D Lickiss Robert P Davies

A siloxane-based hexacarboxylic acid (L1-H6) has been prepared and applied in MOF construction. L1-H6 itself crystallizes as an unusual interpenetrated 3D hydrogen-bonded framework. Reaction of L1-H6 with Zn(ii) gave IMP-18 - a 3D MOF incorporating Si-O-Si functionality. Cleavage of L1-H6 gives a silanol-based triacid which is shown to give a coordination polymer (IMP-19) with Zn(ii).

Journal: :The Journal of biological chemistry 2000
A Gual A G Camacho J C Alonso

The terminase of bacteriophage SPP1, constituted by a large (G2P) and a small (G1P) subunit, is essential for the initiation of DNA packaging. A hexa-histidine G2P (H6-G2P), which is functional in vivo, possesses endonuclease, ATPase, and double-stranded DNA binding activities. H6-G2P introduces a cut with preference at the 5'-RCGG downward arrowCW-3' sequence. Distamycin A, which is a minor gr...

2017
Tianwei Jiang Wei Wu Huasheng Zhang Xiangsheng Zhang Dingding Zhang Qiang Wang Lei Huang Ye Wang Chunhua Hang

B7-H6, a new member of B7-family ligand, also known as NCR3LG1, plays an important role in NK cells mediated immune responses. Many studies have shown that it is highly expressed in various human cancers, and its expression levels are significantly associated with cancer patients' clinicopathological parameters and postoperative prognoses. But, still the exact role of B7-H6 expression in human ...

2009
Heinrich zu Dohna Jinling Li Carol J. Cardona Joy Miller Tim E. Carpenter

The spread of highly pathogenic avian influenza virus (AIV) (H5N1) underlines the potential for global AIV movement through birds. The phylogenies of AIV genes from avian hosts usually separate into Eurasian and North American clades, reflecting limited bird migration between the hemispheres. However, mounting evidence that some H6 sequences from North America cluster with Eurasian subtype H6 s...

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