We report a case of 52-year-old female with steroid-unresponsive Hashimoto's encephalopathy. She underwent plasma exchange that resulted in marked clinical improvement.

within the ␣-synuclein molecule, which self-aggregates to 2 Department of Pathology form amyloid and is an efficient seed for formation of A␤ subsequently found to belong to a larger family of molecules , including ␤-synuclein (or phosphoneuroprotein 14) (Jakes et al. We characterized ␤-synuclein, the non-amyloidogenic molecule is a natively unfolded protein (Weinreb et al., homolog of ␣-synucl...

In autoimmune hypothyroidism (Hashimoto's disease), TPO (thyroid peroxidase) antibodies may be detected, while in autoimmune hyperthyroidism (Graves' disease) thyroid-stimulating hormone (TSH ) receptor antibodies (TSH -R-AB s) are frequently present. Less well known is the fact that autoimmune hypothyroidism can present with TSH-R-ABs and ophthalmic Graves' disease (OGD). This condition is als...

Hypothyroidism is frequently associated with different neuromuscular disorders. However, myotonia is rarely a revealing feature. We report a case of hypothyroidism secondary to Hashimoto's thyroiditis and myotonia. The patient is a 45-year-old woman who consulted for a progressive myotonia. Blood and thyroid assessments revealed peripheral hypothyroidism with low free thyroxine, high thyroid-st...

症 例 患者:29歳,女 性.主 訴:頭 痛,高 血圧.既 往歴,家 族歴:特 記すべ きことな し.現 病歴: 1995年 よ り尿 蛋白,1998年 よ り高血圧 を指摘 さ れる も放置.こ の ころか ら頭痛発作 を繰 り返 し ていた.2000年 の検診で高血圧,尿 蛋 白,尿 潜 血,貧 血,心 電 図異常 を指摘 され,同 年7月13 日当院を初診.初 診時身体所見:意 識清明,身 長160cm,体 重52kg,体 温36.8°C,血 圧240/140 孤mHg,上 下肢差 ・左右差な し,脈 拍80/分 整, 胸 部にラ音 ・心雑音 を聴取せ ず.腹 部平坦軟, 血管雑音 を聴取 せず.下 腿 に浮腫 な し.胸 水 ・ 腹水 を認めず.神 経学 的異常所 見な し.眼 底に 高血圧性 網膜症(Keith-Wagener III度)を 認め, 悪性高血圧B群 と診断 ...

A 25 year old female presented with hypothyroidism which was followed by the development of hyperthyroidism about 1 1/2 years later. This uncommon phenomenon is postulated to result from changes in the relative amounts of stimulatory and inhibitory TSH receptor antibodies. This case illustrates the possible continuum between Graves' disease and Hashimoto's thyroiditis within the broad spectrum ...