In a pilot study, it was established that specific therapy by standard anti-hepatitis B virus (HBV) vaccination may be effective in reducing HBV replication and canceling the immune tolerance to hepatitis B surface antigen (HBsAg) particles in about 50% of persons with chronic active HBV replication. In the present study, the vaccine-induced immune responses were analyzed during an ongoing cont...

OBJECTIVE To investigate the mechanism underlying the development of chronic hepatitis B virus infection (HBV) in Turkish population using HLA tissue typing. METHODS The study group I consisted of 20 patients with HBV-related chronic liver disease (cirrhosis, chronic active hepatitis or chronic persistent hepatitis). The study group II included 30 HBV chronic carriers. The control group consi...

This study investigated the prevalence of the precore G1896A mutation in Chinese patients with hepatitis B e antigen (HBeAg) negative HBV infection and its relation to serum HBV pre-S1 antigen. The overall prevalence of the precore G1896A mutation was 72.6% in HBeAg-negative Chinese patients with detectable serum HBV DNA. The prevalence of the precore G1896A is significantly higher in Chinese H...

INTRODUCTION Despite significant improvement in Anti-HBV vaccination and treatment, HBV infection continues to be a major global health problem. It has been reported that as much as 350 million carriers exist in the world and about one million of them will die annually (1). The prevalence of HBV infection in Iran ranged between 2.7 to 7.2 %, which declined below 2% following national vaccinatio...

background: blood transfusion plays a great role in public health and the blood safety still has remained a main concern. hbv has been considered as one of the most prevalent blood borne infections. it is estimated that chronic hbv affects 350-400 million people worldwide. comprehensive knowledge about hbv has high importance in iran due to high number of blood dependent patients. material and ...

BACKGROUND Accurate and personalized molecular virological diagnosis of hepatitis B virus (HBV) infection is crucial for individualized selection of patients for antiviral therapy in Romania. OBJECTIVES We aimed to investigate HBV mutations in Romanian patients with chronic HBV infection, also to match HBV genotypes with HBV mutations identified and clinical outcomes. PATIENTS AND METHODS T...

Previously, I have reported the laparoscopical and histological findings of 16 chronic HBs Ag carriers in whom the time of HBV infection could be assumed, HBs Ag in the sera persisted for at least 6 months, and laparoscopy with liver biopsy was performed. In these carriers, no abnormal results of liver function tests were found and early history of hepatitis was unknown. Besides these 16 HBs Ag...

INTRODUCTION Hepatitis B virus (HBV) infection is the main cause of chronic liver disease in Iran (1,2). The epidemiology of HBV infection in Iran has been changed during the last two decades (1) and infantile vaccination with high coverage is the main cause for this change (3,4). The prevalence of hepatitis B surface antigen (HBsAg) in the country was reported between 2.5% and 7.2% in 1979 (5)...

T-cell immunoglobulin domain and mucin domain-containing molecule-3 (Tim-3) was up-regulated on viral specific T cells and contributed to T cells exhaustion during chronic hepatitis B virus (HBV) infection. However, modulation of Tim-3 expression was still not fully elucidated. To evaluate the potential viral and inflammatory factors involved in the inductor of Tim-3 expression on T cells, 76 p...