Three novel dinuclear Cu(II) complexes based on a N,N,O-chelating salphen-like ligand scaffold and bearing varying aromatic substituents (?H, ?Cl, ?Br) have been synthesized characterized. The experimental computational data obtained suggest that all three exist in the dimeric form solid state adopt same conformation. mass spectrometry electron paramagnetic resonance results indicate structure ...

Introduction: One of the combination therapies for the treatment of cancer is ultrasound with other agents, which has received considerable attention in recent years. Ultrasound causes cavitation phenomenon that can produce some effects, such as; Reactive Oxygen Species (ROS), which results in damage to cancer cells. When a particle is in liquid, the cavitation threshold decrea...

A facilitated transport process that removes the endogenous cannabinoid anandamide from extracellular spaces has been identified. Once transported into the cytoplasm, fatty acid amide hydrolase (FAAH) is responsible for metabolizing the accumulated anandamide. We propose that FAAH contributes to anandamide uptake by creating and maintaining an inward concentration gradient for anandamide. To ex...

phenolic compounds including flavonoids and phenolic acids are plants secondary metabolites. due to their ability to act as antioxidant agents, there is a growing interest to use those components in traditional medicine for cancer prevention or treatment. the aim of this study was to measure the amounts of total phenolics and flavonoids as well as anti-proliferative effect of aqueous extract of...

objective: lactobacilli are a group of probiotics with beneficial effects on prevention of cancer. however, there is scant data in relation with the impacts of probiotics in late-stage cancer progration, especially metastasis. the present original work was aimed to evaluate the anti-metastatic and anti-proliferative activity of lactobacillus rhamnosus supernatant (lrs) and lactobacillus crispat...

Abstract Background CSN5, a member of Cop9 signalosome, is essential for protein neddylation. It has been supposed to serve as an oncogene in some cancers. However, the role CSN5 not investigated cervical cancer yet. Methods Data from TCGA cohorts and GEO dataset was analyzed examine expression profile clinical relevance The on cell proliferation lines, Siha Hela, through knockdown via CRISPR–C...

HeLa cells grown in tissue culture have certain components in common with normal human tis sues. For example, Miller and Hsu (6) have shown that antiserum prepared against HeLa cells in rabbits is cytotoxic for fibroblasts and epithelial cells derived from adult and newborn skin and also from tonsils, as well as for HeLa. Moreover, the anti-HeLa serum gave a precipitate with an extract of human...

Ophiocoma erinaceus Muller &Troschel (Ophiocomidae) is part of the extensive group of echinoderm that contains bioactive metabolites. As, the anti cancer potential of brittle star saponin has not been reported against cervical cancer, the present study was conducted to evaluate the anticancer effect of extracted crude saponin. Saponin extraction was conducted using conventional method such as f...

It has been reported that several conifers possess cytotoxic activities on some human tumor cell lines. Taxol as a natural cytotoxic compound has been extracted from this family. In a program to screen the cytotoxic effects of natural resources, male and female branchlets, fruit or bark of two different species of Iranian conifers were collected, identified and the cytotoxic effects of their hy...