This paper deals with a capacitated hub location problem arising in the design of telecommunications networks. The problem is different from the classical hub location problem in two ways: the cost of using an edge is not linear but stepwise and the capacity of an hub restricts the amount of traffic transiting through the hub rather than the incoming traffic. In this paper both an exact and a h...

Hepatocellular carcinoma (HCC) has a high incidence and mortality worldwide, and its carcinogenesis and progression are influenced by a complex network of gene interactions. A weighted gene co-expression network was constructed to identify gene modules associated with the clinical traits in HCC (n = 214). Among the 13 modules, high correlation was only found between the red module and metastasi...

BACKGROUND Hepatocellular carcinoma (HCC) is one of the most common types of cancer worldwide. Despite several efforts to elucidate molecular mechanisms involved in this cancer, they are still not fully understood. METHODS To acquire further insights into the molecular mechanisms of HCC, and to identify biomarkers for early diagnosis of HCC, we downloaded the gene expression profile on HCC wi...

Backgroud: Protein-protein interaction, plays a key role in signal transduction in signaling pathways. Different approaches are used for prediction of these interactions including experimental and computational approaches. In conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins inter...

Connectivity in the developing hippocampus displays a functional organization particularly effective in supporting network synchronization, as it includes superconnected hub neurons. We have previously shown that hub network function is supported by a subpopulation of GABA neurons. However, it is unclear whether hub cells are only transiently present or later develop into distinctive subclasses...

This paper proposes a Watts and Strogatz-model based routing method for wireless sensor network along with link-exchange operation. The proposed routing achieves low data-collection delay because of hub-node existence. By applying the link exchanges, node with low remaining battery level can escape from a hub node. Therefore, the proposed routing method achieves the fair battery-power consumpti...

It is a major scientific theoretical significance and practical value that the identification of the hub node in the transport network. This paper presents a new method which can detect the hub node of the urban transportation based on the idea of local modularity measure. Evaluation indicators include node degree, clustering coefficient, peak hour traffic flow. First, apply a complex network o...

Parcel delivery is a complex logistic service, as it serves many small or medium-sized customers who may send or receive parcels. Modeling such delivery system needs to integrate two different research areas of hub location and vehicle routing. As it totally depends on the network and the linkage of the nodes, in this paper, some door-to-door service providers are taken into account to provide ...