نتایج جستجو برای: hla dqa
تعداد نتایج: 40138 فیلتر نتایج به سال:
Aim Oral chemotherapy using anticancer drugs would improve the clinical practice and the life quality of patients. The aim of the present study was to develop paclitaxel hybrid nanomicelles for oral administration to treat resistant breast cancer. Methods Evaluations were performed on human breast cancer MCF-7 cells, drug-resistant breast cancer MCF-7/Adr cells, and in MCF-7/Adr-xenografted B...
Little is known about the major histocompatibility complex (MHC) in the genome of Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis) (YFP) or other cetaceans. In this study, a high-quality YFP bacterial artificial chromosome (BAC) library was constructed. We then determined the organization and characterization of YFP MHC class II region by screening the BAC library, followe...
Background and purpose: Major histocompatibility antigens are the most polymorphic components of the immune system. The purpose of this study was to determine the frequency of human leukocyte antigens (HLA) in a population in Mazandaran province, Iran. Materials and methods: In a cross sectional study, peripheral blood samples were obtained from 550 people in Immunogenetics Research Center af...
Background: The HLA class I molecules serve as ligands for both T cell receptors and killer cell immunoglobulin-like receptors (KIRs). Objective: We investigated the HLAC and HLA-Bw4 alleles as well as KIRs expression on CD56 positive lymphocytes to evaluate whether these genes and molecules could influence Ankylosing spondylitis (AS) susceptibility, alone or in combination. Methods: We typed 4...
Background: Graves’ disease (GD), a highly rampant autoimmune disorder of the thyroid gland, is responsible for 60-80% of the clinical cases of hyperthyroidism. Over the past decades, genetic association studies have identified several GD susceptibility loci in CTLA-4, TSHR and major histocompatibility complex regions. The information on the association between the human leukocyte antigens (HLA...
Objective: This study aimed to investigate the association between HLA alleles and visceral leishmaniasis (VL) in a sample of Iraqi patients. Methods: A total of 30 patients were studied, in addition to 20 age, gender and ethnicity matched controls. All subjects were genotyped by polymerase chain reaction-sequence specific primers (PCR-SSP) method. Results: For HLA-class I region (A and B loci)...
Background: There are several evidences that genetic factors besides environmental triggers have important role in initiating the rheumatoid arthritis (RA). The aim of this study was to investigate the association of rheumatoid arthritis with different subtypes of HLA DR4 in Iranian patients. Methods: In an un-matched case control study, 110 rheumatoid arthritis patients (case) and 56 knee ost...
� زمینه و هدف : بیماری سلیاک بیماری گوارشی است که عوامل ژنتیکی در بروز آن دخیل می&rlmباشند. مطالعه حاضر با هدف تعیین HLA DQ2 و HLADQ8 در بیماران با سرولوژی مثبت سلیاک تشخیص داده شده در بین بیماران مبتلا به سندرم روده تحریک پذیر انجام گرفت. � روش کار: این مطالعه توصیفی تحلیلی مقطعی بر روی 105 بیمار مبتلا به سندرم روده تحریک پذیر مراجعه کننده به درمانگاه گوارش مرکز آموزشی درمانی امام خمینی اردبیل...
A random sample of 500 healthy unrelated subjects from Esfahan province were HLA typed for A, 8 and C locus antigens. The lymphocytes were separated from 5 ml of whole peripheral blood and were typed for HLA _ A, 8 and C by using the standard two stage microlymphocytotoxicity NIH technique. The findings suggest that in the study population, frequency of HLA-Al' A2, A3, Ag HLA-8s, 83S and HLA-CW...
مقدمه: آنتی ژن های لکوسیتی انسان 1 (HLA) به دلیل وجود ارتباط بین برخی آلل های HLA با بیماریهای مختلف، در ارزیابی استعداد ابتلا به بیماریها و کمک به تشخیص آنها اهمیت دارند. بر اساس بسیاری از تحقیقات انجام شده در سراسر دنیا، قویترین این ارتباطات بین آنتی ژن HLA-B27 و اسپوندیلوآرتروپاتیها، بخصوص اسپوندیلیت آنکیلوزانت (جمود التهابی مهره های کمری ستون فقرات)، وجود دارد. هدف از این تحقیق...
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