نتایج جستجو برای: hpv18
تعداد نتایج: 577 فیلتر نتایج به سال:
Using archived specimens, we evaluated a new automated real-time PCR assay (BD Diagnostics) that detects all carcinogenic human papillomaviruses (HPV) and provides HPV genotyping for seven of them, including HPV16 and HPV18, the two most carcinogenic HPV genotypes. We found comparable results with Hybrid Capture 2 (HC2) for detection of carcinogenic HPV (n = 473) and with Linear Array and Line ...
Immunotherapy with VGX-3100 (HPV16 and HPV18 plasmids) + INO-9012 (DNA encoding IL-12) in human papillomavirus (HPV) associated head and neck squamous cell carcinoma (HNSCCa): interim safety and immunogenicity results Charu Aggarwal, Roger Cohen, Matthew P Morrow, Joshua Bauml, Gregory Weinstein, Jean Boyer, Xuefei Shen, Jian Yan, Jessica Goldenberg, Drishty Nashit, Sandra Oyola, Jessica Lee, L...
چکیده مقدمه: ویروس پاپیلومای انسانی نوع 16 و 18 علت 70% سرطانهای مهاجم سرویکس در سراسر دنیاست. کم و بیش در %70-50 زنان پس از عفونت اکتسابی HPV 16 و 18 پادتن تولید میشود. این پادتنها دستکم به مدت 5-4 سال باقی میمانند. هدف: تعیین سطوح پادتن HPV 16 و 18 در سرم بیماران دچار سرطان سرویکس و نتایج پاپ اسمیر CIN I,II,III و ارتباط آن با ناهنجاری سرویکس در خانمهای فعال جنسی که پیشینه ناهنجاری سروی...
in 2008, Harald Zur Hausen received the nobel Prize in physiology and medicine for showing that two human papilloma viruses, HPV16 and HPV18, were associated with the bulk of cervical cancers, and that some of the genes contained within the viruses were incorporated into the infected host tissue, resulting in carcinogenesis. These carcinogenic strains of HPV cause 70% of cervical cancer and kil...
AIM To investigate the relation of human papillomavirus (HPV) and esophageal squamous cell carcinoma (ESCC) in Iranian patients as compared to normal controls. METHODS Using MY09/MY11 consensus primers, we compared the prevalence of a HPV L1 gene in tumor tissues from 38 ESCC cases and biopsied tissues from 38 endoscopically normal Iranian individuals. We also compared the presence of HPV16 a...
Repression of the endogenous human papillomavirus (HPV) type 18 E7 gene in HeLa cervical carcinoma cells by the bovine papillomavirus E2 transcription factor activates the retinoblastoma (Rb) pathway and induces cells to undergo senescence. To determine whether activation of the Rb pathway is responsible for senescence in response to HPV18 E7 repression, we tested the ability of wild-type and m...
Papillomavirus replication in vivo requires the interaction of the virally encoded proteins E1 and E2 with the origin of replication which is localised in the regulatory region (long control region or LCR) of the viral genome. In genital human papillomaviruses (HPVs), the origin overlaps promoter elements of early transcription. In this study, we analysed the replication of HPV18 DNA using the ...
β-Human papillomavirus (β-HPV) DNA is present in some cutaneous squamous cell carcinomas (cuSCCs), but no mechanism of carcinogenesis has been determined. We used ultra-high-throughput sequencing of the cancer transcriptome to assess whether papillomavirus transcripts are present in these cancers. In all, 67 cuSCC samples were assayed for β-HPV DNA by PCR, and viral loads were measured with typ...
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