UNLABELLED Hub proteins (those engaged in most physical interactions in a protein interaction network (PIN) have recently gained much research interest due to their essential role in mediating cellular processes and their potential therapeutic value. It is straightforward to identify hubs if the underlying PIN is experimentally determined; however, theoretical hub prediction remains a very chal...

conclusions our results revealed the possible crucial genes and mirnas involved in the initiation and progression of hcc cells infected with hcv. results based on the topological analysis of mirna-hubgene network, we identified the key hub mirnas. in order to identify the most important common sub-network, we aligned two ppi networks using netal tool. the c-jun gene was identified as the most i...

OBJECTIVES To quantify geographical concentration of falciparum malaria cases in the UK at a hospital level. To assess potential delay-to-treatment associated with hub-and-spoke distribution of artesunate in severe cases. DESIGN Observational study using national and hospital data. SETTING AND PARTICIPANTS 3520 patients notified to the Malaria Reference Laboratory 2008-2010, 34 patients tre...

Regional Knowledge Hub for HIV/AIDS Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran DVM, Regional Knowledge Hub for HIV/AIDS Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Regional Knowledge Hub for HIV/AIDS Surveillance, Institute for Futures Studies in Health, Kerman Universi...

 We introduce a dynamic and stochastic transportation problem consisting of two subproblems. For parcel transportation in hub-and-spoke networks, swap containers are used to carry out hub-to-hub shipments. This constitutes a pickup and delivery problem on the operational level. On the tactical level, empty swap containers are balanced over the hub-network in order to match the stochastic deman...

To function properly, tissue-specific stem cells must reside in a niche. The Drosophila testis niche is one of few niches studied in vivo. Here, a single niche, comprising ten hub cells, maintains both germline stem cells (GSC) and somatic stem cells (CySC). Here, we show that lines is an essential CySC factor. Surprisingly, lines-depleted CySCs adopted several characteristics of hub cells, inc...

Abstract— DC hubs are centrally located in DC grids and they are expected to operate autonomously under wide range of operating conditions. To achieve secure operation without intervention from dispatcher and to damp the internal oscillatory modes, a distributed power balance and damping controller for high power multiport LCL (Inductor-Capacitor-Inductor) DC hub is proposed in this paper. Nat...

A p-hub center network design problem is definition of some nodes as hubs and allocation of non-hub nodes to them wherein the maximum travel times between any pair of nodes is minimized. The distinctive feature of this study is proposing a new mathematical formulation for modeling costs in a p-hub center problem. Here, instead of considering costs as a linear function of distance, for the first...

This paper deals with a capacitated hub location problem arising in the design of telecommunications networks. The problem is different from the classical hub location problem in two ways: the cost of using an edge is not linear but stepwise and the capacity of a hub restricts the amount of traffic transiting through the hub rather than the incoming traffic. In this paper both an exact and a he...