BACKGROUND In developing country like BANGLADESH, people depend more on pharmacies due to expediency, shorter waiting time, cost reduction, availability of credit and flexible opening hours. The aim of this study was to investigate medicines dispensing patterns of the pharmacies in RAJSHAHI, BANGLADESH and to identify and analyze contribution of drugsellers and quacks in irrational drug use. ...

OBJECTIVES While the recreational use of prescription medications is widely recognized as a growing public health issue, there are limited epidemiological studies on patterns of use in Canada, particularly studies identifying populations at highest risk. The objective of this study was to describe recreational prescription drug use among Canadian adolescents by age, sex, socio-economic, immigra...

The author reviewed the relatively poor literature on the topic and its key clinical trial reports on perazine, a classical antipsychotic most frequently prescribed in Poland for psychoses, especially for schizophrenia. Based mainly on the Leucht and Hartung's metaanalysis as well as on other authors' trials with broader context of typical and atypical neuroleptics comparisons, it could be conc...

The term 'barbiturate' refers to drugs which are derivatives of barbituric acid (malonylurea). Barbituric acid itself has no significant psychotropic properties, but its derivatives may have a variety of effects on the central nervous system. Certain of those compounds with significant depressant or sedative-hypnotic properties are of primary importance in medical and nonmedical use. Many of th...

Surveillance studies are useful to evaluate how a new medicinal product performs in everyday treatment and how the patient who takes it feels and functions, thereby determining the benefit/risk ratio of the drug under real-life conditions. Prolonged-release melatonin (PRM; Circadin) was approved in Europe for the management of primary insomnia patients age 55 years or older suffering from poor ...

Stonier, P.D., A.C. Parrott, and 1. Hindmarch: Clobazam in combination with nomifensine (HOE 8476): effects on mood, sleep, and psychomotor Performance relating to car-driving ability. Drug Dev. Res. S1:047-055, 1982. The effects of three dose regimens of HOE 8476, a combination of nomifensine (25 mg) and clobazam (7.5 mg), placebo, and a combination of amitriptyline (25 mg) and chlordiazepoxid...

We describe a method for simultaneous quantitation of diazepam and its metabolites, N-desmethyldiazepam and oxazepam, by reversed-phase liquid chromatography with ultraviolet detection at 254 nm. After extraction with chloroform at pH 11.0, the organic extract is evaporated, and the residue is reconstituted in a small volume of mobile-phase and chromatographed. Concentrations as low as 12 to 20...

Background Psychotropic medications work on the brain to affect mental function and behaviour. For over 20 years, concern has been raised over the overuse of psychotropic medication, particularly antipsychotics and benzodiazepines (‘sedatives’) in nursing homes. The Reducing Use of Sedatives (RedUSe) project was developed as a multistrategic, interdisciplinary initiative aimed to promote the qu...