The effects of different a-D-Glucose (Glu) concentrations (0-16 mM) on Na+, K+-ATPase and Mg2+-ATPase activities were investigated in homogenates of adult male rat whole brain at 37 degrees C. The enzyme activities were determined after 1 h preincubation with Glu. Brain Na+, K+-ATPase was not affected by Glu different concentrations. On the contrary, Mg2+-ATPase activity was considerably reduce...

hypoglycemic agent along with metformin. Although the management of diabetes was attempted by the “experts” of the Pharaoah of Egypt 3500 years ago and by Shushruta, the modern times efforts began only in the in the early 1900. In the year 1937, hypoglycemic activity of sulfur compounds was noted, and five years later, Michel Janbon noted hypoglycemia while using antibiotic para amino sulfonami...

The rhizome of Anemarrhena asphodeloides is used as food and traditional Chinese medicine for its hypoglycemic effect. The aim of this study was to investigate the isolation, purification and hypoglycemic activity of Anemaran as the active component. The influence factors (isolation duration, ratio of residuals to water and extracting times) during the isolation process were evaluated. The opti...

The traditional system of the medicine remains the major source of the health care. It is safe alternative, lesser cost and better tolerance and its complications. The major defense against free radical compounds found in medicinal plants is in the form of natural antioxidants. The present investigation is an attempt to assess the bioactivity of daily oral administration of methanolic extract o...

Abstract Diabetes mellitus is a metabolic disease characterized by hyperglycemia resulting from either defect in insulin secretion, insulin action, or both. Postprandial hyperglycemia is a prime characteristic of diabetes mellitus and has been a focus in the therapy for diabetes. One of the therapeutic approaches which involve decreasing hyperglycemia aims at lowering blood glucose...

Pioglitazone is a thiazolidinedione derivative used for the treatment of type 2 diabetes. The drug's poor aqueous solubility and slow dissolution rate are the main causes of its limited therapeutic action in some cases. The aim of the present study is to formulate a more soluble product of pioglitazone at physiological pH. The potential interaction of pioglitazone with cyclodextrins and water-s...

Synthesis and pharmacological evaluation of guanidinederivatives with potential hypoglycemic activity Patrícia de Albuquerque Sarmento, Polliane Maria Cavalcante-Araújo, Igor Santana de Melo, Paulo Henrique Barcellos França, Návylla Candeia de Medeiros, Tales Lyra de Oliveira, Thaís Honório Lins, Regina Célia Sales Santos Veríssimo, Maria Lysete de Assis Bastos, Êurica Adélia Nogueira Ribeiro, ...

N-hydroxyethyl phthalimide (PE-I) was prepared by refluxing phthalic anhydride with ethanolamine. 3phthalimidoethyl substituted benzoic acids (PE-II) were prepared by refluxing N-hydroxyethyl phthalimide with substituted benzoic acids. The corresponding acid chlorides (PE-III) were condensed with benzilidine-4acetophenone derivatives to afford the 3-(phthalimidoethyl)-4-substituted cinnamoyl su...

Abstract: Background: From the wide range of previous literature studies indicated that thiazolidinedione’s reacts with substituted benzaldehydes undergoes knoevenagel condensation gives respective arylidene derivatives. In our attempt all titled compounds were designed and developed by replacement furan- 2-aldehyde, so furan moiety was introduced in molecule. Materials Methods: 5-[(furan-2-yl)...