Introduction: Concomitant therapy with antiresorptive/antiangiogenic drugs is common in cancer management and reported to have a modifying effect on MRONJ development. M-TOR inhibitors antiangiogenic immunosuppressive properties.Case report: A case of 62 years old female history who developed recurrent mandibular osteonecrosis following few administration sole Everolimus here.

Immunosuppressive drugs are the cornerstone of treatment auto-immune inflammatory diseases (AIIDs) with renal involvement. How‑ ever, most commonly used in this setting can increase risk bacterial, fungal, and viral infection, also impair immune response following vaccination. Recommendations evidence on strategies for infection prevention AIIDs will be reviewed.

Although highly active antiretroviral therapy (HAART) has dramatically changed the epidemiological impact of HIV infection, many problems with currently used antiretroviral therapy have underscored the urgent need for additional therapeutic approaches. Structured treatment interruption trials, which can be considered an immune-based therapy with an autologous virus, have failed to control viral...

PREVIOUS reports of 18 patients with Wegener's Granulomatosis treated with immunosuppressive and cytotoxic drugs are reviewed, and 4 new cases are reported. The prognosis in these patients is shown to be significantly better than that found in previous series where such drugs were not used. Introduction Wegener's Granulomatosis—WG—is generally distinguished from other polyarteritic conditions b...

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The in vitro interaction of antifungals with immunosuppressive drugs was evaluated against zygomycetes. The combination of amphotericin B with cyclosporine, rapamycin, or tacrolimus was synergistic for 90%, 70%, and 30% of the isolates, respectively. For posaconazole, itraconazole, and ravuconazole, synergy was more frequently observed with cyclosporine than with rapamycin or tacrolimus and ant...

The treatment of inflammatory and autoimmune diseases is challenging because of their frequency and complexity. Treatment of these diseases is based on the suppression of the patient's immune system using corticosteroids, corticosteroid-sparing immunosuppressive agents, and biologic drugs, making an understanding of the management of immunosuppressive therapy essential. Before an immunosuppress...