We consider a control problem for a single bioreaction occuring in a continuous and well mixed bioreactor, assuming that the bioreaction’s kinetics is not represented by a validated model. We develop a nonlinear controller and prove the global asymptotic stability of the closed loop system towards the equilibrium corresponding to the set point. Since this control law needs the knowledge of some...

In the present study, the influence of superficial gas velocity and fluid properties on gas holdup and liquid circulation velocity in a three-phase external loop airlift column using polystyrene (0.0036 m diameter and 1025.55 kg/m density) and nylon-6 (0.0035 m diameter and 1084.24 kg/m density) particles with aqueous solutions of alcohols (isoamyl alcohol and propanol) as liquids were investig...

Quality, quantity, and economy of the fermentation product depend on transient response steady-state process. Due to its simple construction, an industrial batch bioreactor cannot be equipped with a closed-loop control system that applies adding or removing substances during fermentation. This theoretical practical study displays how can controlled, in this case by altering rotational speed sti...

There are several animal models illustrating dry eye pathophysiology. Current study would like to establish an ex vivo tissue culture model for characterizing dry eye. Human conjunctival explants were cultured under airlift or submerged conditions for up to 2 weeks, and only airlifted conjunctival cultures underwent increased epithelial stratification. Starting on day 4, the suprabasal cells di...

Coupled level set and CFD (computational fluid dynamics) methods are adopted in this work to track the moving gas–liquid interfaces riser of an external loop airlift photobioreactor (ALR) which microalgae used produce biofuels capture CO2 from flue-gas. Modeling behavior gas bubbles is a crucial aspect for fine-tuning operation reactor when inserted into closed-loop biorefinery at pilot-scale. ...