Background: The identification of miRNAs that play a role in the regulation viral life cycle and its related liver illness opens door to development diagnostic biomarkers can categorize patients at higher risk for developing end-stage disease. This study was designed investigate hepatitis-induced chronic disease (CLD) Egyptian population, as well their potential possible hepatitis virus infecti...

Hepatitis A virus (HAV) is typical enterovirus that may cause liver damage. This infection vary in intensity from a few weeks of moderate sickness to many months severe illness. It sometimes lead failure and death, especially individuals with preexisting health condition or compromised immune system. most common children developing countries. very tiny percentage those who have hepatitis die fu...

Background: The microRNA (miRNA) mediated translational repression can cause various diseases in humans. liver-specific miRNA (microRNA-122 (miR-122)) is primarily involved tissue tropism during hepatitis C virus (HCV) infection which ultimately leads to hepatocellular carcinoma (HCC). Objectives: This study focuses on evaluating host serum miR-122 as a prognostic marker HCV-induced carcinoma. ...

Background and Aim: Hepatitis A virus (HAV) is known to cause several extra hepatic complications including acute acalculous cholecystitis (AAC). ACC due HAV in children usually considered an uncommon complication of viral hepatitis with only 7 cases described literature so far children. To retrospectively investigate the Incidence clinical outcomes induced India. Methods: retrospective review ...

Although liver dysfunction is not considered the main organ pathology or prognostic factor in patients with Systemic Lupus Erythematosus (SLE), it is not uncommon during the course of SLE. Liver complications in patients with SLE may be caused by lupus hepatitis (SLE-related hepatitis); autoimmune liver diseases, such as Autoimmune Hepatitis (AIH) and Primary Biliary Cirrhosis (PBC); viral hepa...

AIM To study the differences in immune response and cytokine profile between acute liver failure and self-limited acute hepatitis. METHODS Forty-six patients with self-limited acute hepatitis (AH), sixteen patients with acute liver failure (ALF), and twenty-two healthy subjects were involved in this study. The inflammatory and anti-inflammatory products in plasma samples were quantified using...

BACKGROUND Autochthonous hepatitis E has been observed with growing incidence in industrialized countries. Hepatitis E virus infection causes an acute hepatitis with spontaneous resolution in the majority of cases. However, in individual cases, hepatitis E may lead to life-threatening acute liver failure. In this report, we describe a case of acute liver injury caused by an autochthonous hepati...

Index 1. Introduction 6 1.1. Hepatitis C Virus Infection 6 Epidemiology and natural history of hepatitis C 6 The Hepatitis C Virus 6 Insulin Resistance in chronic hepatitis C 7 1.2. Non alcoholic fatty liver disease (NAFLD) 8 1.3. Overexpression of PP2Ac in chronic hepatitis C 8 Interferon (IFN) signaling is inhibited in chronic hepatitis C 8 Protein Phosphatase 2A (PP2A) 8 Upregulation of PP2A...

objectives the aim was to study the prevalence of thrombocytopenia in hcv patients without cirrhosis and splenomegaly. patients and methods a cross-sectional study was carried out in the gastrointestinal out patient department (g.i. opd) of the sindh institute of urology and transplantation (siut) from september-november 2013. 30 patients aged between 18 - 60 years with a positive anti-hcv resu...

Isoniazid (INH), one of the most important drugs used in antituberculosis (anti-TB) treatment, is also the major drug involved in hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, such as NAT2, CYP2E1, GSTM1 and GSTT1, that code for drug-metabolising enzymes. Our goal was to examine the polymorphisms in these enzymes as susceptibili...