hepatic toxicity is the most serious adverse effect of anti tuberculosis drugs. this study was performed to evaluate efficacy of silymarin as a hepatoprotective herbal agent. in a randomized double blind clinical trial 70 new cases of pulmonary tuberculosis were divided into two groups. the intervention group was assigned to receive silymarin and the control group received placebo. tuberculosis...

adverse effects of antituberculosis agents such as hepatotoxicity may reduce treatment effectiveness, because they significantly contribute to nonadherence and eventually result in treatment failure, relapse or the emergence of drug resistance. garlic is an ancient herbal substance, which its effectiveness on isoniazid and rifampicin-induced hepatic injury in animal models has been demonstrated...

introduction drug-induced liver injury is a frequent cause of hepatic dysfunction. several drugs have been identified to cause autoimmune hepatitis (aih). environmental chemicals are capable of triggering a certain degree of liver injury. however, toxin induced aih is rare. conclusions chronic (long-term) exposures to dichlorvos can lead to aih. a detailed inquiry of medical history and liver b...

background: hepatotoxicity is a major concern during tuberculosis (tb) drug therapy. its prevalence ranges from 1%-4% in developed countries to 11.5% in developing countries, and is even higher in countries such as india. disease mortality is 5%, but can be prevented by early detection. this study reveals the revalence and outcome of drug-induced hepatitis (dih) in positive sputum tb patients t...

the present study has been directed to investigate ursodeoxycholic acid (udca) effect in children, to reduce the high liver transaminases induced by anticonvulsant drugs (drug induced hepatitis). this idea has been driven from cytoprotective and antioxidant properties of udca to be used in drug induced inflammation in liver. twenty two epileptic patients aged between 4 mo - 3 yr whom were under...

Scientific review covers current data regarding the role of quercetin in therapeutic corrections various liver diseases, particular non-alcoholic fatty disease, chronic hepatitis, drug-induced disease. The aim was to sum up scientific properties, its mechanism action and possibilities this flavonoid treatment diseases.Conclusions. Quercetin is found possess antioxidant, anti-inflammatory, hypol...

cholestatic hepatitis induced by prolonged administration of nalidixic acid: anti biotics like other drugs may generally produce hepatic benign lesions. we have recently observed a case of cholestatic hepatitis by prolonged administration of nalidixic acid. this hepatitis have regressed rapidly after discont inuin-c the dru g. this case dose not excluded the value of nalidixic acid asa strong a...

reversibility of hepatitis virus b – induced cirrhosis