BACKGROUND/AIMS High-resolution manometry (HRM), with a greatly increased number of recording sites and decreased spacing between sites, allows evaluation of the dynamic simultaneous relationship between intrabolus pressure (IBP) and esophagogastric junction (EGJ) relaxation pressure. We hypothesized that bolus transit may occur when IBP overcomes integrated relaxation pressure (IRP) and analyz...

Recurrent pericarditis is a common complication of acute pericarditis (15-30%) for which, in most cases, no underlying etiology is found [idiopathic recurrent pericarditis (IRP)]. IRP is currently viewed as an autoinflammatory disease with characteristic recurrent episodes of sterile inflammation. According to the most recent Guidelines, the initial treatment regimen consists of a combination o...

OBJECTIVES To determine the ability of lactoferrin in rheumatoid arthritis (RA) synovial fluid to bind "free" iron, and to study the regulatory mechanisms therein that control iron homeostasis. METHODS "Free" iron was determined by the bleomycin assay and lactoferrin concentrations by enzyme linked immunosorbent assay. The activities of iron regulatory protein (IRP) and NF-kappa B in synovial...

• We study the Inventory Routing Problem with Time Windows (IRPTW). provide a mixed integer linear programming formulation that includes both arc and routebased variables. develop an efficient branch-price-and-cut algorithm to solve IRPTW optimally. generate two sets of data considering time-varying time-invariant demands at retailers. demonstrate efficacy our solution approach through computat...

Abstract Understanding visitor preferences to heritage areas is essential in informing management planning and interpretive strategies for these places. This paper uses a quantitative method approach investigate local Malaysian trails the Old Town of central Kuala Lumpur, Malaysia, understand what values qualities visitors are experiencing that informs their preferences. The findings this resea...

Liquid chromatography tandem mass spectrometry (LC-MS/MS) based methods provide powerful tools for the quantitative analysis of modified proteins. We have developed a label-free approach using internal reference peptides (IRP) from the target protein for signal normalization without the need for isotope labeling. Ion-trap mass spectrometry and pseudo-selected reaction monitoring (pSRM) were use...

Water, sodium, potassium, ATP, amino acids, and sugars are not uniformly distributed in Rana pipiens oocytes. Concentration differences exist between nucleus (germinal vesicle) and ooplasm and between animal and vegetal ooplasmic regions. The mechanisms responsible for these differences were investigated using intracellular reference-phase (iRP) analysis. The iRP is an artificial "organelle" th...

One major reason for doing evaluations of information systems is to take actions based on the results of the evaluation. In order to make better use of interpretive evaluation processes in practice we need to understand what kinds of results such evaluations produce and the way that the results are used to be transformed into change and betterment in the organisation. We have developed, applied...

Background and Aim: The growing healthcare expenses, technological advancements and increasing competition in healthcare services, brings up new challenges for healthcare industry in providing appropriate services to customers. The Lean methodology, which is a managerial approach, provides tools necessary to eliminate waste and increase customer satisfaction through increasing quality of the se...