BACKGROUND Fever occurring in a neutropenic patient remains a common life-threatening complication of cancer chemotherapy. The common practice is to admit the patient to hospital and treat empirically with intravenous broad-spectrum antibiotics. Oral therapy could be an alternative approach for selected patients. OBJECTIVES To compare the efficacy of oral antibiotics versus intravenous (IV) a...

Antepartum mastitis is a rare condition, whereas postpartum or lactation mastitis is a common problem. This report introduces a case of complicated bilateral antepartum mastitis, which was treated successfully by drain insertion and antibiotic therapy. The patient was a 23-year-old woman in the 23rd week of her first pregnancy. Her chief complaint was progressive swelling, redness and radicular...

newborns’ bacterial infections due to group b streptococcus (gbs) happen in two forms including early-onset disease or late-onset disease. in this paper, we report a case of early-onset gbs infection in a male infant. a 22-year-old primigravid woman delivers a term normal looking male infant. nasal flaring, grunting, and poor feeding presented soon after birth. an empiric treatment with intrave...

Burkholderiacepacia is a rarely diagnosed infection in Nepal. Most cases of B.cepaciaare reported from South East Asia. It can present with wide spectrum clinical manifestations ranging pneumonia to septicemia. We case 29-year-old man who had acute pancreatitis and was admitted the hospital due sepsis. B.cepaciawas isolated ascitic fluid successfully treated intravenous antibiotics. Bangladesh ...

The use of human venous endothelial cells for testing antibiotic solutions for intravenous compatibility provides a valuable alternative to animal models. In order to evaluate the effect of vancomycin and teicoplanin on the viability of human umbilical venous endothelial cells, intracellular ATP levels were measured by a luciferin-luciferase assay. Prostacyclin (PGI2) and thromboxane A2 (TXA2) ...

BACKGROUND Intrathecal administration of antibiotics has potentially high effectiveness for the treatment for severe intracranial infections, particularly nosocomial meningitis. The use of intrathecal injection of antibiotics has been reported mostly in case reports. However, there is sparse data regarding the pharmacokinetics of antibiotics after intrathecal administration. AIM This study in...

Abstract A woman in her nineties presented with a 7-day history of right upper quadrant pain, nausea and anorexia. Examination findings included tenderness the positive Murphy’s sign. Laboratory studies were unremarkable normal white cell count, C-reactive protein liver functions tests. Ultrasound abdomen, however, demonstrated distended gallbladder containing sludge thickened wall. The patient...

The pharmacokinetics of gentamicin, kanamycin, and creatinine were studied in patients undergoing hemodialysis. After intravenous injection of single doses of the drugs, 50 to 60% of the doses of both antibiotics were cleared from the body during a 6-h period; this occurred almost entirely by the hemodialysis process. No correlation was found between the dialysance of the aminoglycosides and cr...

BACKGROUND Early conversion from intravenous to oral antibiotics plays an important role in lowering the risk of catheter-associated infections, reducing the workload of nurses, decreasing direct and indirect costs, and shortening hospital stays. In August 2015, an antimicrobial stewardship program (ASP) was implemented to facilitate conversion from intravenous to oral administration of fluoroq...

The pharmacokinetics of gentamicin, kanamycin, and creatinine were studied in patients undergoing hemodialysis. After intravenous injection of single doses of the drugs, 50 to 60% of the doses of both antibiotics were cleared from the body during a 6-h period; this occurred almost entirely by the hemodialysis process. No correlation was found between the dialysance of the aminoglycosides and cr...