Twenty-four clinical cases of dogs presented for surgical interventions requiring general anaesthesia were randomly divided into four groups (n=6) irrespective age, breed, sex, body weight and procedure. The animals group I II first premedicated with atropine sulphate @ 0.02 mg/kg BW butorphanol 0.2 intramuscularly; whereas, buprenorphine was administered intramuscularly in III IV, followed by ...

Diazepam was metabolized to three primary metabolites, 3-hydroxy-diazepam, N-desmethyl-diazepam, and p-hydroxy-diazepam. Our previous studies reported metabolic position-specific inter- or intrastrain differences in diazepam metabolism among Sprague-Dawley, Brown Norway, Dark Agouti, and Wistar rats. Especially, there were marked ( approximately 300 fold) inter- or intrastrain differences in di...

The characteristics of recovery from total intravenous anesthesia (TIVA) with propofol and inhalation anesthesia with isoflurane was clinically compared in 149 client-owned dogs that anesthetized for surgical or diagnostic procedures. In all dogs, anesthesia was induced with an intravenous injection of propofol following premedication with acepromazine or diazepam. As a result, 58 dogs anesthet...

Myocardial blood flow was measured by the 133Xe clearance method in 6 patients with radiologically confirmed disease of the coronary arteries and in 4 patients with normal arteries. The myocardial bloodflow was measured 5 minutes after intravenous diazepam OI mg/kg body weight. There was an increase in myocardial bloodflow in all cases. Patients with normal coronary arteries showed an average i...

Mesobuthus martensii Karsch, commonly known as the Chinese scorpion or Manchurian scorpion, has been used in traditional Chinese medicine as Quanxie to treat chronic pain, tetanus, tremors, convulsion, and paralysis for more than a thousand years. We report a case of poisoning after ingestion of a teaspoon of Quanxie powder. The patient presented with chest pain, dizziness, diaphoresis, general...

The intravenous anaesthetic ketamine has been given to patients undergoing minor gynaecological surgery after atropine prcmedication in initial doses ranging from 1.0 to 3.0 mg/kg. The chief induction complications were hypertension and hypertonus, the incidence of which was only broadly related to dosage. Recovery of consciousness was rapid, though marred by a high incidence of delirium at all...

Short-term memory following the intravenous injection of methohexitone (0.15 mg/kg), diazepam (0.05 mg/kg) and sodium 4-hydroxybutyrate (10 mg/kg) has been examined by means of a visually presented digit retention test with intervals of 4 and 20 seconds before recall. No significant change was found with the 4-second interval; statistically significant impairment was found with the 20-second in...

Lycium schweinfurthii is found in stony and sandy places belonging to the Solanaceae family which widely distributed North Africa Mediterranean area. The leaves fruits of this plant have traditionally been used for gastrointestinal diseases. This study was aimed evaluate neuropharmacological activity methanolic extract experimental animals. prepared by fractionation technique. Male Albino mice ...

Rats were trained to discriminate between saline and either 0.3, 1.0, 3.0 or 6.0 mg/kg of diazepam in a two-choice, discrete-trial avoidance procedure. Diazepam, chlordiazepoxide, flurazepam and pentobarbital occasioned dose-related increases in diazepam-appropriate responding in all four training dose groups. Increasing the training dose of diazepam from 0.3 to 1.0 mg/kg resulted in approximat...

In the present study, the effects of caerulein and CCK receptor antagonist< on tolerance to the anti-pentylenetetrazol activity of diazepam has been studied. Different doses of diazepam (20, 30, 35, 40 and 50 mg/kg) were administered intraperitoneally for a period of 6 days in order to induce tolerance to diazepam. 48 h after the last dose of diazepam, a test dose of diazepam was tested for...