OBJECTIVES To compare mortality rates between dopamine-sensitive (Dopa-S) and dopamine-resistant (Dopa-R) septic shock patients, the latter group defined by a mean arterial pressure <70 mm Hg despite the use of 20 mug/kg/min dopamine. DESIGN A human, prospective observational, multiple-center, clinical trial. SETTING Ten intensive care units from ten hospitals. PATIENTS 110 patients with ...

Brain energy state and glycolytic metabolites were measured in young (6 month) and aged (28 month) male rats under normoxic (70% nitrous oxide, 30% oxygen) or hypoxic (PaO2 = 25 mm Hg) test conditions. Hypoxic ischemia was induced in one cerebral hemisphere by ligation of one carotid artery. Under normoxic test conditions brain energy metabolite concentrations were similar between young and age...

in order to investigate effective morpho-physiological traits related to salinity resistance, and their relationship with grain yield as well as study of salinity tolerance and susceptibility indices in 169 barley recombinant inbred lines, a  population of barley derived from a cross between arigashar and igri, this experiments were carried out using alpha lattice design with two replications d...

The mammalian blastocyst exhibits a high capacity for aerobic glycolysis, a metabolic characteristic of tumours. It has been considered that aerobic glycolysis is a means to ensure a high carbon flux to fulfil biosynthetic demands. Here, alternative explanations for this pattern of metabolism are considered. Lactate creates a microenvironment of low pH around the embryo to assist the disaggrega...

The purpose of this study was to evaluate the effect of creatine supplementation in the diet on indicators of glucose metabolism in skeletal muscle of exercised rats. Forty Wistar adult rats were distributed into four groups for eight weeks: 1) Control: sedentary rats that received balanced diet; 2) Creatine control: sedentary rats that received supplementation of 2% creatine in the balanced di...

Purpose: BackgroundIschemia reperfusion(IR) increases lactate.No one has examined if cardiac-specific coronary sinus lactate(CSL)can be reduced with prior cytoprotective heat shock protein 70(hsp70i) induction. We previous demonstrated improved IR in vivo inducted hsp70i.Geranylgeranylacetone(GGA), an hsp70i inducer, never been administered IV preischemically. Interventions to decrease CSL may ...

We examined the variability and determinants of the respiratory exchange ratio (RER) at rest and during exercise in 61 trained cyclists. Fasting (10-12 h) RER was measured at rest and during exercise at 25, 50, and 70% of peak power output (W(peak)), during which blood samples were drawn for [lactate] and [free fatty acid] ([FFA]). Before these measurements, training volume, dietary intake and ...

continual heat stress affects approximately 7 million hectares of wheat in developing countries, while terminal heat stress is a problem in 40% of temperate environments, which cover 36 million hectares throughout the world. heat tolerance is a quantitative and complex trait that doesn’t have much success in direct selection. for this purpose, however, a thorough understanding of physiological ...

3,4-Dihydroxycinnamic acid (3,4-DA) is a natural compound with high antioxidant potential found in various foods. This study found that animals administered with 3,4-DA had higher exercise tolerance, reduced blood lactate, and markers of hepatic oxidation. Blood glucose and antioxidant enzymes were not affected by this treatment. 3,4-DA may have applicability in reducing the fatigue associated ...