Lymphocyte activation gene-3 (LAG-3; CD223), a structural homolog of CD4, binds to MHC class II molecules. Recent research indicated that signaling mediated by LAG-3 inhibits T cell proliferation, and LAG-3 serves as a key surface molecule for the function of regulatory T cells. Previous reports demonstrated that the majority of LAG-3 is retained in the intracellular compartments and is rapidly...

Possible physiological mechanisms to explain the flash-lag effect, in which subjects perceive a flashed item that is co-localized with a moving item as trailing behind the moving item, have been found within the retina of lower species, and in the motor pathways of humans. Here, we demonstrate flash-lag employing "second-order" moving and flashed stimuli, defined solely by their binocular-dispa...

CONTEXT Prolonged transmeridian air travel can impart a physical and emotional burden on athletes in jet lag and travel fatigue. Jet lag may negatively affect the performance of athletes. STUDY TYPE Descriptive review. EVIDENCE ACQUISITION A Medline search for articles relating to jet lag was performed (1990-present), as was a search relating to jet lag and athletes (1983-January, 2012). Th...