Aim: To analyse whether there are changes in sodium and potassium serum levels during chronic treatment with the diphenyl methanes bisacodyl and sodium picosulfate. Methods: A literature search was done using PubMed, and the reference lists of pertinent papers were screened for additional studies. Only studies of at least 4 weeks duration were considered for further analysis. Results: Four rele...

Because of the laxative effect of capsaicin, we examined the effect of that agent on the electromyogram of the isolated cat colon. At a concentration of 10(-4)M, it caused a significant reduction in the frequency of the electrical slow waves in the proximal half of the colon. Frequency fell to its lowest value, 45% of control (P less than 0-001), in the most proximal 10% of the organ below the ...

Objective: Many studies have shown that non-motor symptoms can precede the decline of cognitive and motor function in neurocognitive disorders, and constipation is known to be one of them. Our aim is to evaluate cognitive functions in Korean elderly taking laxatives due to constipation. Method: We used data from the Korean Longitudinal Study on Health and Aging (KLoSHA), which is a community-ba...

Objective: Many studies have shown that non-motor symptoms can precede the decline of cognitive and motor function in neurocognitive disorders, and constipation is known to be one of them. Our aim is to evaluate cognitive functions in Korean elderly taking laxatives due to constipation. Method: We used data from the Korean Longitudinal Study on Health and Aging (KLoSHA), which is a community-ba...

An 18 year old girl presented with a leiomyosarcoma of the small bowel with widespread dissemination. Despite short term remissions after chemotherapy and surgery she died of the disease 10 months later. A history of prolonged exposure to danthron (an anthraquinone laxative) in childhood was obtained. Anthraquinones are known to be mutagenic and may be carcinogenic in experimental systems but d...

BACKGROUND Constipation within childhood is an extremely common problem. Despite the widespread use of osmotic and stimulant laxatives by health professionals to manage constipation in children, there has been a long standing paucity of high quality evidence to support this practice. OBJECTIVES We set out to evaluate the efficacy and safety of osmotic and stimulant laxatives used to treat fun...

Mercury is found in the environment as elemental mercury, inorganic mercury or organic mercury (ethyl-, methyl-, alkyl-, or phenylmercury). In our environment it is present in thermometers, thermostats, dental amalgams, paint, cosmetic products, laxatives, diuretics and antiseptics. Organic mercury is the most toxic and most frequent form of mercury exposure, found in fish, poultry, pesticides ...