Table 1. Symptom – Based Treatment of Irritable Bowel Syndrome Pain Predominant Diarrhea Predominant Constipation Predominant Antispasmodic Agents  Dicycloverine (Bentyl)  Mebeverine Tricyclic Antidepressants  Amitriptyline Antidiarrheal Agents  Loperamide (Imodium)  Cholestyramine (questran) Serotonin (5-HT3) antagonist  Alosetron (Lotronex)  Ondansetron (Zofran) Serotonin (5-HT4) Agoni...

QUESTION Many of my patients experience constipation during pregnancy, even after increasing dietary fibre and fluids. Are there any safe treatments I can recommend to them? ANSWER Although the recommended first-line therapy for constipation includes increasing fibre, fluids, and exercise, these are sometimes ineffective. Therefore, laxatives such as bulk-forming agents, lubricant laxatives, ...

Main results 14 studies (12 randomised controlled trials, 843 children) met the selection criteria. Children had encopresis in 12 studies and faecal incontinence resulting from congenital abnormalities in 2 studies. Study duration was 2–6 weeks in 6 studies, 8–18 weeks in 6 studies, and 12 months in 1 study. 8 studies compared conventional treatment (laxatives, dietary advice, and toilet traini...

Phenolphthalein, the active ingredient in many laxatives, was recently found to be a carcinogen in animal models. Human data suggest a laxative-colon cancer association, but few data specifically address the effects of phenolthalein-containing laxatives. We examined use of phenolphtalein-containing laxatives in relation to occurrence of adenomatous colorectal polyps in data from three case-cont...

Introduction Laxatives are commonly used to treat opioid-induced constipation, the commonest and most bothersome complication of opioids. However, laxatives have a nonspecific action and do not target underlying mechanisms of opioid-induced constipation; their use is associated with abdominal symptoms that negatively impact quality of life. Objective To assess the effects of laxatives in pati...

Constipation is a commonly reported disorder in many patients. Constipation treatment using laxatives on regular and long term basis can lead to patient dependence, especially among the elderly. However, there scanty data habit-forming potential of Indian constipated This review has explored literature evidence expert opinion patients’ experience regarding attributes stimulant osmotic la...

On the therapy of constipation, there are few reports that surveyed the actual circumstance of patients taking laxatives and the effectiveness of the drug. In this study, we investigated the contents in prescription, the actual conditions of administration of laxatives, and the subjective symptoms of inpatients in all wards of Kanazawa University hospital (2000. 12.1-2000. 12. 10). As a result ...