Visceral leishmaniasis (VL), is an infection due to obligate intracellular protozoa of the genus Leishmania[1]. Natural transmission of the parasite happens primarilyby way ofthe bite of contaminated female of phlebotome. In the Old World it is represented by the genus Phlebotomous but in the New World it is called Lutzomyia. Another way of transmission may occur among the intravenous drug abus...

An Eritrean-born man observed over an extended period had upper gastrointestinal symptoms, fever, hepatosplenomegaly and pancytopenia in the setting of advanced HIV infection and poor adherence to antiretroviral therapy. Despite thorough investigation, it was not until a repeat gastroscopic examination and gastric biopsy were performed 18 months after initial presentation that Leishmania infect...

Leishmania are obligate intracellular vector-borne parasites that cause significant morbidity and mortality in many countries worldwide. There are several species of the parasite which vary according to geographical location and cause a variety of clinical syndromes ranging from self-limiting cutaneous lesions to potentially fatal infection of the viscera. The disease manifested is dependent on...

partially purified antigenic fractions of leishmania major promastigotes were obtained by sodium dodecyl sulfate (sds-page) and electro-elution. three isolated protein fractions designated as frac tions (fr.) 1, 2, and 3 correspond to 40-60, 60-80, 80-100 kilodalton (kda) respectively. they were used for immunization of balb/c mice against leishmaniasis. the effects of these fractions on immune...

INTRODUCTION The present study was designed to assess the occurrence of co-infection or cross-reaction in the serological techniques used for detecting the anti-Leishmania spp., -Babesia canis vogeli and -Ehrlichia canis antibodies in urban dogs from an area endemic to these parasites. METHODS The serum samples from dogs were tested for the Babesia canis vogeli strain Belo Horizonte antigen a...

The aim of the work is to summarize available literature data on cases visceral leishmaniasis in children registered Russian Federation, as well describe our own clinical observation autochthonous a 9-year-old child, diagnosis which polymerase chain reaction (PCR) method was used. Materials and methods: review domestic foreign over past 20 years, including Internet resources, carried out. We ob...

Infection with Leishmania infantum causes the disease visceral leishmaniasis (VL), which is a serious clinical and veterinary problem. The drugs used to treat canine (CanL) do not cause complete parasite clearance; they can be toxic, emerging drug resistance in populations limits their utility. Therefore, this study we have evaluated toxicity efficacy of joint treatment 1:1 mixture sodium stibo...

Several studies have suggested that the PCR could be used in epidemiological mass-screening surveys to detect Leishmania (Viannia) spp. infection in human and animal hosts. Dogs from an area of Leishmania braziliensis and Leishmania peruviana endemicity were screened for American cutaneous leishmaniasis (ACL) infection by established PCR-based and enzyme-linked immunosorbent antibody test (ELIS...

To mimic the sandfly pool feeding process and characterize the cellular and biochemical events that occur during the early stages of promastigote-host interaction, we developed an ex vivo model of human blood infection with Leishmania promastigotes. Within 30 s of blood contact, Leishmania promastigotes bind natural anti-Leishmania antibodies, which then activate the classical complement pathwa...

American cutaneous leishmaniasis (ACL) is a major public health problem caused by vector-borne protozoan intracellular parasites from the genus Leishmania, subgenera Viannia and Leishmania. Asymptomatic infection is the most common outcome after Leishmania inoculation. There is incomplete knowledge of the biological processes explaining the absence of signs or symptoms in most cases while other...