background: zoonotic cutaneous leishmaniasis (zcl) is an expanding disease and public health problem in iran. in the current study, natural leishmania infection rate and seasonal fluctuation of the infection in rhombomys opimus population of a hyperendemic focus of zcl in iran was investigated. methods:   the study was conducted from october 2006 to october 2008 in esfahan province, central par...

Mixed infections with different Leishmania species could explain differences in the clinical courses of these infections. On identification of Leishmania parasites from Iranian patients with mucosal leishmaniasis (ML), a patient with both oral and nasal lesions was found to be concomitantly infected with Leishmania tropica and L. major. Mixed infection was identified by PCR amplification of Lei...

BACKGROUND Zoonotic cutaneous leishmaniasis (ZCL) is an expanding disease and public health problem in Iran. In the current study, natural Leishmania infection rate and seasonal fluctuation of the infection in Rhombomys opimus population of a hyperendemic focus of ZCL in Iran was investigated. METHODS The study was conducted from October 2006 to October 2008 in Esfahan Province, central part ...

Parasites belonging to Leishmania braziliensis, Leishmania donovani, Leishmania mexicana complexes and Trypanosoma cruzi (clones 20 and 39) were searched in blood, lesions and strains collected from 28 patients with active cutaneous leishmaniasis and one patient with visceral leishmaniasis. PCR-hybridization with specific probes of Leishmania complexes (L. braziliensis, L. donovani and L. mexic...

26 Mixed infection by different Leishmania species could explain differences in the clinical 27 course of these infections. On identification of Leishmania parasites from Iranian patients 28 with mucosal leishmaniasis (ML), a patient with both oral and nasal lesions was found to be 29 concomitantly infected with L. tropica and L. major. Mixed infection was identified by PCR 30 amplification of ...

This study investigated whether Leishmania species, the etiologic agent of cutaneous (Leishmania major) and visceral (Leishmania donovani) leishmaniasis, could differentially elicit early inflammatory events in vivo correlating with the subsequent development of their reciprocal pathogenesis. By use of the murine air pouch system, injection of Leishmania led to a rapid and transient accumulatio...

background: leishmaniasis is a worldwide disease prevalent in tropical and sub tropical coun­tries. many attempts have been made and different strategies have been approached to develop a potent vaccine against leishmania . dna immunisation is a method, which is shown to be effec­tive in leishmania vaccination. leishmania soluble antigen (sla) has also recently been used leishmania vaccination....

We have infected BALB/c and C57BL/6 mice with a cloned Leishmania mexicana amazonensis population, obtained from the "Maria" strain. Progression of infection and histopathological examination confirmed the extreme susceptibility of BALB/c mice and the resistant pattern of the C57 BL/6. Anti-Leishmania antibody titers were higher in BALB/c than in C57BL/6 mice through the period of infection. Te...

background: canine visceral leishmaniasis (cvl) is a systemic disease with a high mortality rate, caused by a diphasic protozoan parasite, leishmania infantum/chagasi in the world. the objective of the present study was to determine the presence of cvl in the city and suburbs of kerman, using a range of serological, histopathological and molecular methods. methods: blood samples were taken from...

Background. Endemic areas of tegumentary leishmaniasis (TL) in Salta, Argentina, present some overlap zones with the geographical distribution of Chagas disease, with mixed infection cases being often detected. Objectives. The purpose of this study was to determine the magnitude of Leishmania sp. infection and potential associated risk factors, the serologic prevalence of T. cruzi, and the pres...