Background: Due to high genetic variation in human leukocyte antigen )HLA( alleles, epitope-based vaccines don’t show equal efficacy in different human populations. therefore, we proposed a multi-epitope vaccine against SARS-CoV-2 for Iranian populations. Materials and Methods: For this purpose, the proteins without allergenicity and high antigenicity as well as conservancy level from SARS-CoV...

variety of positive as well as negative regulatory signals are provided by antigen presenting cell in particular by dendritic cells. in this research, we studied the capacity of dendritic cells to expand antigen-specific t regulatory cells.we also investigated the role of tgf-beta in induction inhibitory functions of dendritic cells in mixed leukocyte reactions. dendritic cells were generated f...

successful clearance of hepatitis b virus (hbv) is a promising event in which host's immune system will attempt to get rid of the virus. the immunological events of hbsag seroclearance have attracted great attention in both natural history investigations and therapeutic trials. recent genome-wide association studies (gwas) has confirmed polymorphisms in the human leukocyte antigen (hla)-dp locu...

The cell-mediated immune response of cattle to Mycoplasma mycoides var. mycoides was studied. Sensitized lymphocytes in blood leukocyte preparations showed a significant degree of antigen-induced transformation, judged by the uptake of tritiated thymidine. The increase in tritiated thymidine uptake in sensitized lymphocytes in the presence of M. mycoides membrane antigen varied from 2- to 13-fo...

OBJECTIVE Kawasaki disease (KD) clinically presents as a systemic vasculitis syndrome with significant cardiovascular involvement. With different incidence among different ethnic groups, the role of certain human leukocyte antigens and their products has been considered as a crucial predisposing factor in the immune responses in this disease. METHODS We determined the distribution of human le...

T lymphocytes are increasingly recognized as key modulators of detrimental inflammatory cascades in acute ischaemic stroke, but the potential of T cell-targeted therapy in brain ischaemia is largely unexplored. Here, we characterize the effect of inhibiting leukocyte very late antigen-4 and endothelial vascular cell adhesion molecule-1-mediated brain invasion-currently the most effective strate...

Psoriasis is a chronic inflammatory skin disease with strong Th17-skewed immune phenotype. It has been generally accepted that regulatory T cells in the lesional psoriasis have functional impairment. However, circulating Cutaneous Leukocyte Associated antigen(CLA)+ cell which potentially migrated out from not yet explored well so far especially Asians. Herein, to investigate whether CLA+regulat...

Background: During antigen capture and processing, mature dendritic cells (DC) express large amounts of peptide-MHC complexes and accessory molecules on their surface. DC are antigen-presenting cells that have an important role in tolerance and autoimmunity. The transforming growth factor-beta1 (TGF-β1) cytokine has a regulatory role on the immune and non-immune cells. The aim of this study is ...