The mixed dopamine (DA) agonist/antagonist terguride acts as a DA antagonist on normosensitive receptors but shows DA agonistic properties at supersensitive DA receptors. Such a compound could offer an alternative to the treatment of Parkinson's disease with indirect or direct DA agonists. The present study compares the actions of terguride, 4-12 mg/kg i.p., in naive common marmosets with its e...

While the hippocampus makes unique contributions to memory, it has also long been associated with sensorimotor processes, i.e. innate processes involving control of motor responses to sensory stimuli. Moreover, hippocampal dysfunction has been implicated in neuropsychiatric diseases, such as schizophrenia and anxiety disorders, primarily characterized by non-mnemonic deficits in the processing ...

Spinal cord injury (SCI) can lead to locomotor deficits, and the repair of chronic SCI is considered one of the most challenging clinical problems. Although extensive studies have evaluated treatments for acute SCI in small animals, comparatively fewer studies have been conducted on large-animal SCI in the chronic phase, which is more clinically relevant. Here, we used a collagen-based biomater...

Stroke commonly results in substantial and persistent deficits in locomotor function. The majority of scientific inquiries have focused on singular intervention approaches, with recent attention given to task specific therapies. We propose that measurement should indicate the most critical limiting factor(s) to be addressed and that a combination of adjuvant treatments individualized to target ...

Lumbar spinal stenosis (LSS) causes ischemia, inflammation, demyelination and results in dysfunction of the cauda equina (CE), leading to pain and locomotor functional deficits. We investigated whether exogenous administration of S-nitrosoglutathione (GSNO), an endogenous redox modulating anti-neuroinflammatory agent, hastens functional recovery in a CE compression (CEC) rat model. CEC was indu...

Pyrethroids are commonly used insecticides that are considered to pose little risk to human health. However, there is an increasing concern that children are more susceptible to the adverse effects of pesticides. We used the zebrafish model to test the hypothesis that developmental exposure to low doses of the pyrethroid deltamethrin results in persistent alterations in dopaminergic gene expres...

This study tested the hypothesis, derived from studies of normal infants, that experience with self-produced locomotion facilitates the development of two important spatial cognitive skills: a two-position object permanence manual search task, and a task assessing the infant's following of the point/gaze gesture of the experimenter. Both of these tasks, as assessed in these studies, show median...

Studies of Quantum Dots biodistribution have shown that these nanoparticles accumulate in various organs, including brain parenchyma, possibly causing functional alterations. To investigate its potential neurotoxicity, we administered QDs to young mice and studied their behaviour during the following weeks. Spontaneous locomotor behaviour in the home cage was not significantly altered in treate...

s | 27 Results: Social defeat stress as juveniles, even with 1-day exposure, induced robust and persistent deficits of social behaviors in relation to the unfamiliar ICR mouse, compared with the responses of mice exposed to the stress as adults. The stress did not affect anxiety-like behaviors during spontaneous locomotor activity in a novel environment and performance on the elevated plus-maze...

s | 27 Results: Social defeat stress as juveniles, even with 1-day exposure, induced robust and persistent deficits of social behaviors in relation to the unfamiliar ICR mouse, compared with the responses of mice exposed to the stress as adults. The stress did not affect anxiety-like behaviors during spontaneous locomotor activity in a novel environment and performance on the elevated plus-maze...