OBJECTIVE We devised a novel strategy, a GnRH antagonist protocol with a GnRH agonist trigger followed by frozen-thawed blastocyst transfers with long zona dissection (LZD). The purpose of this study was to investigate the clinical outcomes of this new strategy according to age. METHODS Ninety women aged less than 35 (group A) and 32 women aged 35 to 39 (group B) underwent the GnRH antagonist...

Background: Our Background was to evaluate the effect of ovarian endometrioma on ovarian stimulation outcomes in Intra Cytoplasmic Sperm Injection (ICSI). Materials and Methods: In this prospective cohort study, we followed 103 patients underwent ICSI procedures at royan Institute during 10 month. The study group consisted of 46 women who had endometriomawith size more than 1 cm. The control gr...

In an attempt to examine whether body mass index (BMI) may influence IVF outcome in patients undergoing COH with either GnRH-agonist (agonist group) or GnRH-antagonist (antagonist group), we studied 799 IVF cycles: 481 in the agonist group and 318 in the antagonist group. In patients with BMI >25 kg/m(2), COH with either GnRH-agonist or GnRH-antagonist achieved a comparable outcome; whereas in ...

Treatment strategies for the infertile couple with endometriosis must be based on the specific situation. Traditional medical therapy for endometriosis, such as progestins, danazol, and GnRH agonists, have been shown to have little impact on enhancing spontaneous pregnancy rates despite well described beneficial effects on reducing pain. For the young women with only minimal or mild endometrios...

The reports on how to stimulate the ovaries for oocyte retrieval in good prognosis patients are contradictory and often favor one type of controlled ovarian hyperstimulation (COH). For this reason, we retrospectively analyzed data from IVF/ICSI cycles carried out at our IVF Unit in good prognosis patients (aged <38 years, first and second attempts of IVF/ICSI, more than 3 oocytes retrieved) to ...

BACKGROUND Although initial studies in poor responders using GnRH antagonists have reported encouraging results, they are limited in number, only a few of them are prospective, while the majority is characterized by limited power to detect a clinically important difference. METHODS A randomized controlled trial was performed in patients with one or more previous failed IVF cycles in which fiv...