Mitochondria play important roles in cellular energy metabolism, free radical generation, cell signaling and apoptosis. Defects in mitochondrial function have long been suspected to contribute to the development and progression of cancer. Warburg’s pioneering work hypothesized that a key event in carcinogenesis involved changes in metabolism, with malignant cells satisfying their energy needs b...

Ovarian carcinomas exhibit extensive heterogeneity, and their etiology remains unknown. Histological and genetic evidence has led to the proposal that low grade ovarian serous carcinomas (LGOSC) have a different etiology than high grade carcinomas (HGOSC), arising from serous tumours of low malignant potential (LMP). Common regions of chromosome (chr) 3 loss have been observed in all types of s...

The role of serous tumors of low malignant potential (LMP) in the development of invasive epithelial cancer of the ovary is debatable. This review summarizes the current clinical, genetic, and genomic evidence for the existence of a continuum comprising both LMP serous tumors and low-grade serous ovarian carcinomas.

BACKGROUND Complete resection of the thymus is considered appropriate for a thymoma resection because any remaining thymic tissue can lead to local recurrence. However, there are few studies concerning the extent of thymus resection. Therefore, we conducted a retrospective study to investigate whether recurrence following thymoma resection correlated to the extent of resection. METHODS Betwee...

A twenty-five-year-old female presented with a large retroperitoneal mass. Workup included history and physical exam, imaging, biopsy, colonoscopy, and gynecologic exam. After surgical resection, the mass was determined to be a primary retroperitoneal mucinous tumor (PRMT). Clinically and histologically, these tumors are similar pancreatic and ovarian mucinous neoplasms. PRMTs are rare and few ...

BACKGROUND Inverted papilloma (IP) is a benign tumor of the nasal cavity and paranasal sinuses first described by Ward in 1854. IP is remarkable due to a high propensity for tumor recurrence with incomplete resection, potential for invasion of local structures, and an association with malignant transformation to squamous cell carcinoma. Surgery is the mainstay of treatment for sinonasal IP, and...

Borderline ovarian tumors (BOT) were first described in 1929 by Taylor, which, due to the characteristics of the tumor, called it “semi malignant” or “borderline” [1]; subsequently, this group of tumors of the ovary were classified in 1973 by the World Health Organization as “low malignant potential ovarian tumor” [2] and, finally, in 2003 WHO separates them from carcinomas and call them border...

twenty five cases of minor saliva ry glands tumors which was observedat the department of pathology of university of tehran from 1967 to 1972 are presented and discussed . benign mixed tumor is the most common and the only benign lesion in this series of 75 patient with intraoral salivary gland tumor. there were eleven malignant type and hence about 44% of all the tumor arc malignant and it cor...