A bioassay for possible carcinogenicity of technical-grade dibromochloropropane (DBCP) was conducted using Osborne-Mendel rats and B6C3F1 mice. DBCP in corn oil was administered by gavage 5 days a week, at either of two dosages, to groups of 50 male and 50 female animals of each species. Initial dosage levels for the chronic bioassay were selected on the basis of a preliminary subchronic toxici...

Ferric nitrilotriacetate (Fe-NTA) induces renal proximal tubular necrosis, a consequence of lipid peroxidation, that finally leads to a high incidence of renal adenocarcinoma in rats and mice. Male animals are much more susceptible than female animals to both effects. Moreover, the distribution of the susceptible proximal tubules is different between male and female animals. The present study i...

transgenic (tg) mice are very important models of disease, and have been introduced to biological studies since 1982. they are used for understanding the pathobiology of different diseases, finding targets for pharmacological manipulations, and for the evaluation of efficacy and toxicity of medicines in preclinical studies. many different types of tg mice are available as models for human disea...

background: morphine and lidocaine are known to influence the perception of pain. the present study sought to determine the influence of local administration of morphine on lidocaine-induced analgesia in morphine non-dependent (mnd), morphine dependent (md) and morphine withdrawal (mw) animals. methods: adult male wistar rats were divided into four groups: control, mnd, md and mw rats. lidocain...

introduction: depression is one of the most frequent psychiatric disorders in the world with occurs with higher incidence in women. in the present study, the effect of water-alcoholic extract of papaver rhoeas l. on forced swimming test (fst) in swiss-webster mice were examined. methods: we used swiss-webster mice (20-25 g) to execute fst on them. the plant extract (1, 10, 30, and 100 mg/kg) wa...

total, regional and segmental growth rate of vertebral column were studied during the postnatal life of 30 male camels. these animals were into five groups of neonate, 1 y, 2.5-3y, 4-4.5y, 5.5-6y and 7-10 years divided. the results revealed that, although the growth rate was higher in younger animals than the older ones, but it was not constant in an regions and it was varied according to the a...

Sex differences in human immunodeficiency virus type-1 (HIV-1) have been repeatedly suggested. Females, who account for 51% of HIV-1 seropositive individuals, are inadequately represented in clinical and preclinical studies, as well as in the description of HIV-1 associated neurocognitive disorders (HAND). Direct comparisons of neurocognitive decline in women and men must be made to address thi...

Objective. Develop an experimental model of liver cirrhosis and describe pathomorphological changes in organs tissues laboratory animals. Materials methods. Liver was simulated on 11 sexually mature Wistar male white rats. The control group consisted 12 healthy Acute toxic injury resulting induced by intraperitoneal injection 50% tetrachloromethane (CCl 4 ) solution olive oil the first day expe...

The aim of the study was to determine effectiveness using osteotropic drugs for restoration bone defects.
 Materials and methods. model experiment performing on male Wistar rats. animals has been simulated a defect into which implanted:"mp3 Osteobiol" (1st experimental group - 14 animals), PRP coated with fibrin glue (2nd 13 animals) + "mp3 (3rd 15 animals). histological material were stai...

Background: Diabetes is a metabolic disorder that in long period can damage the testis and reduce the semen quality. Therefore, it can impair the male fertility potential. Recently, different herbal therapeutic treatment for protection of diabetes and its pathologic effects have been used. The aim of current study is to evaluate the protective effect of Equisetum arvense extract (EE) on in vitr...