Comparability between a biosimilar and its reference product requires the evaluation of critical quality attributes that may impact on its pharmacological response. Herein we present a physicochemical characterization of a biosimilar trastuzumab focused on the attributes related to the pharmacokinetic response. Capillary isoelectrofocusing (cIEF) and cation exchange chromatography (CEX) were us...

Packaging is classified as one of back-end processes in the integrated circuits (ICs) manufacturing, highly capital-intensive and involves complex processes. Unlike the front-end process that fabricates wafers, the back-end process is rarely uniform. Because of the complexity of the process and increasing variety of products, the packaging foundry occasionally encounters complaints that can be ...

Assigning proper dispatching rules dynamically has been shown to enhance various performance measures for a flexible manufacturing system (FMS). To achieve this, real-time salient information of the system is extracted and then a rule’s dispatching mechanism is built for the scheduling task. For a dynamic scheduled FMS, two critical issues dominate the performance; the first is the selection of...

In order to achieve high punching precision, good operational reliability and low manufacturing cost, the structural optimization of a high-speed press in the presence of a set of available alternatives comprises a heterogeneous multiple-attribute decision-making (HMADM) problem involving deviation, fixation, cost and benefit attributes that can be described in various mathematical forms due to...

technology selection is an important part of management of technology. recently karsak and ahiska (2005) proposed a novel common weight multiple criteria decision making (mcdm) methodology for selection of the best advanced manufacturing technology (amt) candidates based on a number of attributes. however, amin et al. (2006), by means of a numerical example demonstrated the convergence difficul...

The formation of multi-species feeding flocks (MSFFs) through visual recruitment is considered an important strategy for obtaining food in seabirds and its functionality has been ascribed to enhanced foraging efficiency. Its use has been demonstrated in much of the world's oceans and includes numerous species. However, there is scant information on the temporal stability of the composition and ...

In the light of growing global competition, organizations around the world today are constantly under pressure to produce high-quality products at an economical price. The integration of design and manufacturing activities into one common engineering effort has been recognized as a key strategy for survival and growth. Design for manufacturability (DFM) is an approach to design that fosters the...

The definition of usability has evolved over time. Some of the proposed definitions have been general, and apply to all types of interactive systems. Others were tremendously influenced by the experience of those who proposed the definitions and the domain in which they practiced usability. The definitions, in general, seem to agree that the targeted users, the complexity of the task, the type ...

The article addresses the issues of Supply Chain (SC) performance measurement the process of qualifying the efficiency and effectiveness of the supply chain. The aim of this study is to create a supply chain measurement framework for manufacturing industry. The research is based on a review of the current understanding of supply chain management and literature related to supply chain performanc...