Ebolavirus (EBOV) and Marburgvirus (MARV) that compose the filovirus family of negative strand RNA viruses infect a broad range of mammalian cells. Recent studies indicate that cellular entry of this family of viruses requires a series of cellular protein interactions and molecular mechanisms, some of which are unique to filoviruses and others are commonly used by all viral glycoproteins. Detai...

To enter cells, the filovirus, ebolavirus (EBOV), must bind to target cells and internalize into an endocytic vesicle. The properties surrounding filoviral entry into permissive cells remain poorly studied. To date, the kinetics associated with filoviralglycoprotein (GP)-mediated entry have never been investigated past 6 hours. We observed that less than half of the retroviral based pseudovirio...

•CD14+ monocytes show Marburg virus replication after infection of reservoir bats•Infected bat and tissues canonical antiviral response gene induction•Infected host lacks significant induction immunopathogenic genes•Immunoprotective contrasts starkly to that reported for sick primates (MARV) is among the most virulent pathogens primates, including humans. Contributors severe MARV disease includ...

Emerging viral diseases pose a threat to the global population as intervention strategies are mainly limited to basic containment due to the lack of efficacious and approved vaccines and antiviral drugs. The former was the only available intervention when the current unprecedented Ebolavirus (EBOV) outbreak in West Africa began. Prior to this, the development of EBOV vaccines and anti-viral the...

with the advent of islam during the first half of the 7th century ce, pottery manufacture gradually started to change all over the islamic world. at the beginning iranian potters continued their pre-islamic traditions, therefore; nishapur potteries and their motifs can be seen as a link between two most flourishing eras in history of persian art (pre and post islamic period). the samanids were ...

1. introduction according to the main text of shahnameh, the sasanian yazdgerd iii after awareness of defeated his armies toward arabs and to be killed rostam farrukhzad, he consults with the elders of court and says to them “he wants to go of baghdad to marv and stay near ruler there mahoe suri that he is his bred. farrukhzad one of the leaders of that community to yazdgerd says: که این را ی...