OF DISSERTATION DISRUPTIONS IN THE REGULATION OF EXTRACELLULAR GLUTATMATE AFTER DIFFUSE BRAIN INJURY By Jason Michael Hinzman Glutamate, the predominant excitatory neurotransmitter in the central nervous system, is involved in almost all aspects of neurological function including cognition, motor function, memory, learning, decision making, and neuronal plasticity. For normal neurological funct...

BACKGROUND Recent changes to the regulatory landscape of pharmaceuticals may sometimes require reimbursement authorities to issue guidance on technologies that have a less mature evidence base. Decision makers need to be aware of risks associated with such health technology assessment (HTA) decisions and the potential to manage this risk through managed entry agreements (MEAs). OBJECTIVE This...

Accurate mechanics measurements during high-frequency oscillatory ventilation (HFOV) facilitate optimizing ventilator support settings. Yet, these are influenced substantially by endotracheal tube (ETT) contributions, which may dominate when leaks around uncuffed ETT are present. We hypothesized that 1) the effective removal of ETT leaks may be confirmed via direct comparison of measured vs. mo...

We aimed to evaluate knowledge of first aid among new undergraduates and whether it is affected by their chosen course. A questionnaire was developed to assess knowledge of how to activate the Mobile Emergency Attendance Service - MEAS (Serviço de Atendimento Móvel de Urgência; SAMU), recognize a pre-hospital emergency situation and the first aid required for cardiac arrest. The students were a...

The proton exchange membrane fuel cell (PEMFC) technology has drawn considerable attention during past two decades and has potential for automotive applications due to high energy density and low impact on environments [1, 2]. Nevertheless, commercialization of fuel cell vehicles still depends on achieving higher volumetric power density and specific power in order to compete with traditionally...

To decrease the cost of fuel cell manufacturing, amount platinum (Pt) in catalyst layer needs to be reduced. In this study, ionomer gradient membrane electrode assemblies (MEAs) were designed reduce Pt loading without sacrificing performance and lifetime. A two-layer stratification cathode was achieved with varying ratios 28 wt. % inner layer, on membrane, 24 outer coated onto layer. study MEA ...

As a solid-state deposition, cold spray maintains the intrinsic characteristics of feedstock powder. Thus, it provides unique opportunity for depositing high-entropy alloys (HEAs) and medium-entropy (MEAs) that are great interest coatings to protect vulnerable materials from aggressive environments. However, considering high hardness complexity these powder's preparation, choice deposition para...

Arc faults are serious discharges, damaging insulation systems, and triggering electrical fires. This is a transversal topic, affecting from residential to aeronautic applications. Current commercial aircrafts being progressively equipped with arc fault protections. With the development of MEAs, future airliners will require more power enhance fuel economy, save weight, reduce emissions. The ul...