A piperidinyl chlorotriazine (PCT) derivative, used as a plastic UV-stabilizer, caused an outbreak of occupational asthma. We verified, in BALB/c mice, the sensitizing potential of PCT in comparison to a known respiratory sensitizer (toluene diisocyanate [TDI]) and a known dermal sensitizer (oxazolone), using three different methods in order to evaluate the validity of current models of sensiti...

We evaluated the immuno-pulmonary status of employees working at public facilities to determine whether they are at greater risk of developing respiratory allergies. Fifty-two employees from child daycare centers, elderly nursing homes, subway stations, and hypermarkets, and 17 office workers were recruited. All were subjected to a skin prick test (SPT) for 25 aeroallergens and the methacholine...

Within hours, tolerance occurs to repeated methacholine challenge in normal subjects, and this study examines whether prostaglandin synthesis produces this phenomenon. On two separate study days, ten nonasthmatic non-smoking subjects with measurable baseline responsiveness to methacholine performed five sequential methacholine challenge tests over 6 h. Pretreatment before each day consisted of ...

We have read the recent paper by BAcKER and coworkers [1] in which they confirm findings of previous surveys that there is a considerable overlap in bronchial responsiveness between asthmatics and non-asthmatics. Most of these surveys have used a fixed threshold level as a positive test criterion, for instance PC 20 FEV 1 $8 g·l methacholine. However, several studies [2, 3] show that bronchial ...

background: gestational diabetes mellitus (gdm) is the most common metabolic complications of pregnancy and causes fetal mortality and morbidity. therefore early diagnosis of gdm is necessary to reduce maternal and fetal morbidity and to help prevent or delay the onset of type 2 diabetes objective: this prospective study was carried out to determine the incidence of gdm in yazd and to assess th...

BACKGROUND Methacholine hyperresponsiveness is prevalent in elite athletes. Comparative studies have hitherto been limited to methacholine, eucapnic voluntary hyperpnoea and exercise. This study investigated airway responsiveness to these stimuli as well as to adenosine 5'-monophosphate (AMP) and mannitol, in 58 cross-country ski athletes. METHODS Exhaled nitric oxide concentration (F(E)NO), ...

BACKGROUND It has been suggested that exhaled breath temperature (EBT) is increased in asthmatic subjects. OBJECTIVES Our aim was to investigate EBT in asthmatics compared to healthy controls before and after eucapnic voluntary hyperventilation (EVH) and a methacholine challenge test (MCT). METHODS A total of 26 asthmatics and 29 healthy controls were included. Forced expiratory volume in 1...

BACKGROUND Exercise-induced bronchoconstriction (EIB) was recently classified into EIB alone and EIB with asthma, based on the presence of concurrent asthma. OBJECTIVE Differences between EIB alone and EIB with asthma have not been fully described. METHODS We retrospectively reviewed who visited an allergy clinic for respiratory symptoms after exercise and underwent exercise bronchial provo...

OBJECTIVES We aimed to identify the bronchial response to inhaled methacholine in patients with mitral stenosis (MS) and to clarify whether or not the bronchial hyperreactivity (BHR) is reversible after percutaneous mitral balloon valvulotomy (PBMV). PATIENTS AND SETTING Thirty patients with MS and 28 age-matched healthy control subjects were prospectively evaluated with pulmonary function te...

To study the mechanisms and kinetics underlying the development of increased airway responsiveness (AR) after allergic sensitization, animal models have been invaluable. Using barometric whole-body plethysmography and increases in enhanced pause (Penh) as an index of airway obstruction, we measured responses to inhaled methacholine in conscious, unrestrained mice after sensitization and airway ...