chronic cough is a common problem in patients visiting physicians and its prevalence in different populations range from 3 to 40%. postnasal drip, asthma and gastroesophageal reflux are the known cause of chronic cough. although diagnosis of asthma is usually made by clinical signs and spirometeric results, methacholine challenge test is a good diagnostic test in patients who show normal physic...

STUDY OBJECTIVES Validation of test-shortening procedures for the 2-min tidal breathing methacholine challenge method. DESIGN Retrospective chart review. SETTING Tertiary-care university clinical pulmonary function laboratory. PATIENTS One thousand subjects aged 10 to 85 years (mean +/- SD, 44.5 +/- 16.0 years), 44.5% male, referred for methacholine challenge. INTERVENTION Two-minute ti...

Methacholine inhalation challenge has become an accepted test to determine the presence of airway hyperresponsiveness, a hallmark of asthma. To help physicians interpret the results of a methacholine challenge test in a clinical setting, we analyzed the test data of 1,105 subjects, asthmatics and nonasthmatics. Applying Bayes' theorem, a nomogram was constructed incorporating the prechallenge c...

PURPOSE Bronchial hyperresponsiveness (BHR) is typically measured by bronchial challenge tests that employ direct stimulation by methacholine or indirect stimulation by adenosine 5'-monophosphate (AMP). Some studies have shown that the AMP challenge test provides a better reflection of airway inflammation, but few studies have examined the relationship between the AMP and methacholine challenge...

Introduction According to the reports of the United States National Bureau of Statistics regarding the prevalence of obesity among adults and children and also asthma outbreak, the relationship between asthma and obesity in developed countries is taken into consideration. Aim Relationship between body mass index and increased airway reactivity based on methacholine challenge test results. M...