Background: Borderline Personality disorder is a disabling disease affecting 2% of general population. Various drugs have been suggested for treatment of borderline Personality disorder. If a drug could alleviate a wide range of symptoms, it would be more suitable. In these disorders drug addiction is very common. This fact makes the symptoms complicated and the treatment more difficult. This...

We studied 145 clinically euthyroid patients on maintenance methadone therapy for narcotic withdrawal, to characterize abnormalities in thyroid-function tests induced by methadone. About a third had increased total thyroxin (T4) and total triiodothyronine (T3) concentrations in serum. The mean concentrations of T3, T4, and thyroxin-binding globulin (TBG) in serum were significantly greater (P l...

To evaluate driving aptitude and traffic-relevant performance at peak and trough medication levels in opioid-dependent patients receiving maintenance therapy with either buprenorphine (mean: 13.4 mg) or methadone (52.7 mg) and a medication-free control group, the Addiction Clinic at Medical University Vienna conducted a prospective, open-label trial where 40 opioid-dependent patients maintained...

Background & Aims: Methadone maintenance therapy is one of the treatment choices for opiate users. Understanding opiate dependants’ experiences of their treatment period is important for continuing the treatment with methadone and assessing their experiences may help to revise the standards of methadone centers and thus to improve the quality of treatment. This study aims to describe the struct...

Methadone is clinically effective as substitution therapy in patients with opioid dependence. The diversity of methadone and morphine in their intracellular activity is postulated. We compared the effects of repeated daily treatment of Sprague-Dawley rats with morphine (10 mg/kg) and methadone (1 mg/kg) on the expression of the Gα(i1-i3) mRNAs in several rat brain areas using RT-qPCR. We found ...

Opioids are commonly prescribed to patients with chronic pain associated with end-stage renal disease requiring hemodialysis. The stability of opioid analgesia during dialysis may vary among different opioids. No studies to date have corroborated this clinical observation by directly comparing plasma concentrations of different opioids during dialysis. We compared changes in peridialysis plasma...

Objective: Substance dependence is the most critical biopsychosocial and legal problem. It has various harmful effects at the individual, familial, and society levels. The current study aimed to determine the effect of mindfulness-based cognitive therapy on reducing the intensity of substance dependence and improving cognitive emotion regulation in substance-dependent patients under methadone m...