In Ontario, Canada, beta-thalassemia is easily detected through measurement of hemoglobin A2, but most laboratories do not do exhaustive DNA investigations for alpha-thalassemia. Therefore, the prevalence of thalassemia in microcytic samples for hemoglobinopathy investigation in Ontario is unknown. To address this, we performed a prospective cohort study in which samples referred for hemoglobin...

Heterozygous beta-thalassemia (β-thal) carriers are characterized by microcytosis, hypochromia, and elevated HbA2 levels (≥3.5%) [1]. Although an elevated HbA2 level is a diagnostic parameter for β-thal, the interaction between d-globin gene mutation and β-thal can result in a normal HbA2 level, leading to misdiagnosis [2]. As δ-thalassemia (δ-thal) has no clinical significance, a reduced HbA2 ...

A child with congenital hemolytic anemia, extreme microcytosis and bizarre red cell morphology has been studied. Splenectomy at the age of 21 mo greatly improved the hemolytic anemia, although red cell morphology was unchanged. Aniso- and poikilocytosis were marked on a stained smear, and there were many small hyperchromatic cells of irregular shape. The MCV of 25 cu mu was very low and the MCH...

Little is known about the toxicity of immune modulators in fish. Zafirlukast an anti-inflammatory that antagonizes cysteine leukotriene receptors (CysLTR1). Aiming to develop strategies for sanitary management fish farms, this study evaluated clinical safety oral zafirlukast treatment, through biochemical and hematological analyzes during acute inflammatory reaction Nile tilapia (Oreochromis ni...

HbQ-India is a rare alpha chain variant that usually presents in the heterozygous state. Normally, HbQ-India is clinically silent. It becomes symptomatic when present in association with other conditions. We report a case of HbQ-India with concomitant presence of iron deficiency anemia. A 16-year-old female presented with weakness and pallor intermittently for six years. Complete blood count sh...

To the Editor I read with interest the correspondence relating to recent articles published in the Journal describing mathematical approaches to the differentiation of thalassemia trait (TT) and iron deficiency anemia (IDA). 1-3 I found this and the accompanying authors' responses to be thoughtful and informative. There has been a clear revival of interest in the application of discriminant fun...

Objective: Aim was to evaluate the sensitivity and specificity of Mentzer index in differentiating beta thalassemia minor from anemia Iron deficiency. Materials Methods: A cross-sectional study conducted Hematology unit Hayatabad Medical Complex .Sampling done non-consecutively. total 860 cases with value Hemoglobin less than 11 Gm/DL were counted. In all selected full blood count checked Index...