MicroRNAs (miRNAs) are short non-coding RNAs that regulate the expression of protein-coding genes by partially binding to specific target sites of mRNAs. miRNAs perform important functions in complicated cellular biological processes and their abnormal expression is involved in various disorders, including cancer. Among the miRNAs, differential expression of miR-139-5p serves a significant role...

FK 506 is a powerful immunosuppressant currently being investigated in clinical transplantation. I In vivo administration of this drug resulted in the prolongation of skin, liver, kidney, and heart allografts in large and small animal models.2•3 The immunosuppressive effect has also been shown recently to be effective in the prevention of development of diabetes in BB rats.4 In baboons. treatme...

Using a rat model, the effect of pre-treatment with FK 506 on hepatic ischemia/reperfusion injury was investigated. All control animals died within 72 h of the ischemia/reperfusion injury. Pre-treatment of the animals with FK 506 (0.3 mg/kg in 0.5 ml saline) administered intravenously improved survival. The most striking protection against fatal ischemia/reperfusion injury was achieved in rats ...

OBJECTIVES Calcineurin (CN) is a main phosphatase and a critical regulator of cellular pathways for learning, memory, and plasticity. The FK-506 (tacrolimus), a phosphatase inhibitor, is a fungal-derived agent and a common immune suppressant extensively used for tissue transplantation. To further clarify the role of CN in different stages of learning and memory the main aim of this study was to...

We describe a large-scale and complete experiment aiming at validating the hypothesis that the popularity of music titles can be learnt using global acoustic or human features. We use a 32.000 title database with 632 manually-entered attributes per titles including 3 related to the popularity of the title. We design an experiment with two different audio feature sets, as well as the set of all ...

In this paper we present a novel extended formulation for the line planning problem that is based on what we call “configurations” of lines and frequencies. Configurations account for all possible options to provide a required transportation capacity on an infrastructure edge. The proposed configuration model is strong in the sense that it implies several facet-defining inequalities for the sta...

The immunosuppressant FK506 binds Plasmodium falciparum FK-506 binding protein 35 (PfFKBP35) and shows anti-malarial activity. To understand molecular mechanism of the drug on the parasite, we have done NMR studies. Here, we report the assignment of FK506-binding domain of PfFKBP35.

Determining that miRNAs play a role in breast cancer pathogenesis suggests it may be useful the diagnosis and treatment of cancer. In this study, 39 patients with invasive were diagnosed serum levels 20 miRNAs(miR-105, miR-21, miR-141, miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-375, miR-34a, miR-133a, miR-155, miR-139-5p, miR-143, miR-145, miR-365, miR-299-5p, miR-411, miR-452, miR-17)...

The continued growth of MIR is motivating more complex annotation data, consisting of richer information, multiple annotations for a given task, and multiple tasks for a given music signal. In this work, we propose JAMS, a JSON-based music annotation format capable of addressing the evolving research requirements of the community, based on the three core principles of simplicity, structure and ...