Transcatheter valve implantation is a novel interventional technique, which was developed as an  alternative therapy for surgical aortic valve replacement in inoperable patients with severe aortic stenosis. Despite limited experience in using transcatheter valve implantation for mitral and aortic regurgitation, transapical transcatheter aortic valve implantation and valve-in-valve implantation ...

BACKGROUND Significant mitral regurgitation in patients undergoing transcatheter aortic valve replacement (TAVR) is associated with increased mortality. The aim of this study is to determine if surgical correction of both aortic and mitral valves in high risk patients with concomitant valvular disease would offer patients better outcomes than TAVR alone. METHODS A retrospective analysis of 43...

Patients with rheumatic mitral stenosis often have no pulmonary oedema despite considerably increased pulmonary venous pressure. Pulmonary microvascular permeability was measured non-invasively by a previously validated method of double isotope scintigraphy with indium-113m and technetium-99m. This permits calculation of an index reflecting transferrin efflux and thus, indirectly, the microvasc...

17. Shone JD, Sellers RD, Anderson RC, Adams P Jr, Lillihei CW, Edwards JE: The developmental complex of "parachute mitral valve," supravalvar ring of the left atrium, subaortic stenosis and coarctation of the aorta. Am J Cardiol 11: 714, 1963 18. Ellison RC, Restieaux NJ: Vectorcardiography in Congenital Heart Disease. Philadelphia, W.B. Saunders Co, 1972, p 196 19. Heath D, Edwards JE: The pa...

Knowledge of the structural changes in the commissures, cusps, and chordae tendineate is important to the understanding of the pathologic physiology of mitral stenosis and its surgical correction. Study of 70 hearts with mitral stenosis disclosed that a frequent cause of the obstruction was commissural fusion or shortening of the chordae tendineae or both. In a small percentage of hearts, mitra...

BACKGROUND Understanding the mechanism and the main components involved in rheumatic mitral regurgitation (MR) associated with dominant pliable mitral stenosis (MS) may improve our ability to repair some mixed rheumatic mitral valve pathologies. OBJECTIVES To assess mitral valve structural components in pure mitral stenosis versus mitral stenosis associated with mild regurgitation METHODS U...

Valvular disease is common in patients undergoing left ventricular assist device (LVAD) implantation. Concomitant valve surgery increases procedural complexity and cardiopulmonary bypass time and may lead to worse outcomes. Although mitral regurgitation is the most common mitral valve dysfunction in patients undergoing LVAD implantation, mitral stenosis (MS) is occasionally encountered. MS can ...

MITRAL valve disease has for many years been accepted as the commonest sequel of rheumatism, both clinically and pathologically. The development of stenosis has never been in question. Such has not been the case, however, with incompetence, though as long ago as I849 Hope first drew attention to this condition. The existence of mitral incompetence as an entity or even as an important component ...

Many studies of the pressures in the left atrium and the left ventricle of patients with mitral valve disease have been published. Initially obtained by direct puncture of the cardiac chambers at operation, such recordings have since been made possible by the development of techniques of left atrial puncture as a diagnostic procedure before operation. Direct determinations of the left atrial pr...