Models of cognitive control posit a key modulatory role for the pontine locus coeruleus-norepinephrine (LC-NE) system. In nonhuman primates, phasic LC-NE activity confers adaptive adjustments in cortical gain in task-relevant brain networks, and in performance, on a trial-by-trial basis. This model has remained untested in humans. We used the pharmacological agent modafinil to promote low-tonic...

In the present research, a multi-objective model is proposed, which considers equity among the citizens in addition to the cost criterion. Then, the model will be solved using Reservation Level Tchebycheff Procedure (RLTP), which is one of the interactive multi-objective decision-making techniques. Subsequently, the obtained results will be compared with those of the single-objective models to ...

In present study, a three-step multi-objective optimization algorithm of cyclone separators is catered for the design objectives. First, the pressure drop (Dp) and collection efficiency (h) in a set of cyclone separators are numerically evaluated. Secondly, two meta models based on the evolved Group Method of Data Handling (GMDH) type neural networks are regarded to model the Dp and h as the re...

So far, many types of location models have been developed to find optimal spatial patterns according to different spatial metrics such as cost, coverage and availability.  The initial focus of these models is on the location availability of service providers and demand estimates, and some of these models are within the framework of multi-objective programming models.  After the advent of scienc...

To present initial results of a novel, bi-phasic, porous, biodegrade, and cell-free aragonite-based scaffold for treating complex osteochondral lesions the talus (OLT). Four subjects (2 males 2 females; 34-61 years old) were operated on their ankles due to chronic deep OLT-Hepple grades 4 or 5 (1.8-2.2 cm2). Three had OLT medial central trochlea, 1 combined lateral lesions. exposed through mall...

Central neurons express a variety of neuronal types and ion channels that promote firing heterogeneity among their distinct neuronal populations. Action potential (AP) phasic firing, produced by low-threshold voltage-activated potassium currents (VAKCs), is commonly observed in mammalian brainstem neurons involved in the processing of temporal properties of the acoustic information. The avian c...

Uterine contractile activity in nonpregnant conscious dogs was investigated based on 2- to 6-mo-long continuous recording by means of a chronically implanted force transducer. We found that nonpregnant uterine contractile activity could be classified into six major patterns: sporadic contractions, weak and strong tonic contractions, weak and strong phasic contractions, and phasic contraction bu...

............................................................................................ 13 Introduction...................................................................................... 15 Fear and Anxiety............................................................................... 18 Models............................................................................................. ...

STUDY OBJECTIVES Rapid eye movement (REM)-induced hypotonia of the major upper airway dilating muscle (genioglossus) potentially contributes to the worsening of obstructive sleep apnea that occurs during this stage. No prior human single motor unit (SMU) study of genioglossus has examined this possibility to our knowledge. We hypothesized that genioglossus SMUs would reduce their activity durin...