The immunomodulatory drugs (IMiDs) thalidomide, pomalidomide, and lenalidomide are widely used to treat multiple myeloma. permanent need of IMiDs analogues in clinical screening practice has created the demand find a reliable robust method for their preparation. To reach this goal, use flow chemistry is quite appealing, allowing safe operation, an excellent reproducibility efficient process. He...

The Supply Chain is considered a necessity for the success of organizations seeking the most economic, environmental and social impacts. In addition, the implementation and suitable execution of this supply chain seems to be necessary. Considering the importance of the social impacts of this supply chain, a fuzzy multi-objective mathematical model is provided such that, in addition to consideri...

Dyna planning is an efficient way of learning from real and imaginary experience. Existing tabular and linear Dyna algorithms are single-step, because an “imaginary” feature is predicted only one step into the future. In this paper, we introduce a multi-step Dyna planning that predicts more steps into the future. Multi-step Dyna is able to figure out a sequence of multi-step results when a real...

Modelling and forecasting Stock market is a challenging task for economists and engineers since it has a dynamic structure and nonlinear characteristic. This nonlinearity affects the efficiency of the price characteristics. Using an Artificial Neural Network (ANN) is a proper way to model this nonlinearity and it has been used successfully in one-step-ahead and multi-step-ahead prediction of di...

Inspired by previous work on emergent language in referential games, we propose a novel multi-modal, multi-step referential game, where the sender and receiver have access to distinct modalities of an object, and their information exchange is bidirectional and of arbitrary duration. The multi-modal multi-step setting allows agents to develop an internal language significantly closer to natural ...

The paper presents an automated procedure for surface reconstruction from digital images. This method was developed for closerange photogrammetric applications, with a particular attention to terrestrial free-form objects that can be modelled with point clouds extracted from images. Therefore, the paper is not directly concerned with architectural elements, where objects feature breaklines and ...