Abstract Multidrug resistance has been detected in the animal and zoonotic human pathogen Rhodococcus equi after mass macrolide/rifampin antibioprophylaxis endemically affected equine farms United States. Multidrug-resistant (MDR) R. emerged upon acquisition of pRErm46, a conjugative plasmid conferring to macrolides, lincosamides, streptogramins, and, as we describe, tetracycline. Phylogenomic ...

Since multidrug resistance (MDR) is a major cause of failure in cancer chemotherapy, we report a microfluidic approach combined with the same-single-cell analysis to investigate the modulation of MDR, manifested as the inhibition of drug efflux. A microfluidic chip that was capable of selecting and retaining a single multidrug-resistant cancer cell was used to investigate drug efflux inhibition...

One of the major obstacles to the successful chemotherapy towards several cancers is multidrug resistance of human cancer cells to anti-cancer drugs. An important contributor to multidrug resistance is the human multidrug resistance protein-1 transporter (MRP1), which is an efflux pump of the ABC (ATP binding cassette) superfamily. Thus, highly efficacious, third generation MRP1 inhibitors, lik...

OBJECTIVES To report perinatal transmission of multidrug resistant (MDR) HIV related to variable maternal adherence antenatally. METHODS Case study including review of clinic records, adherence information, laboratory data, and HIV genotyping results in mother and infant. RESULTS Poor maternal adherence to clinic visits and antiretroviral therapy contributed to detectable viraemia antenatal...

To overcome multidrug resistance (MDR) in cancer chemotherapy, we prepared various plant extracts and searched for a component which is effective for inhibition of MDR. MDR inhibition activity was determined by measuring cytotoxicity to MDR cells using multidrug resistant human fibrocarcinoma KB V20C, which is resistant to 20 nM vincristine and expresses high level of mdr1 gene. Of various plan...

Tuberculosis (TB) is a global health burden especially in tropical countries. Extensive increments MDR (Multidrug resistance (MDR): Resistance to at least both isoniazid and rifampicin.) XDR (Extensive drug (XDR): any fluoroquinolone, one of three second-line injectable drugs (capreomycin, kanamycin, amikacin), addition multidrug resistance) tuberculosis highlights the ineffectiveness establish...

Multi-drug resistance (MDR), an unfavorable factor compromising treatment efficacy of anticancer drugs, involves upregulated ATP binding cassette (ABC) transporters and activated Sonic hedgehog (Shh) signaling. By preparing human breast cancer MCF-7 cells resistant to doxorubicin (DOX), we examined the effect and mechanism of norcantharidin (NCTD), a small-molecule synthetic compound, on revers...

Multidrug resistance (MDR) is a major problem in the treatment of infectious diseases and cancer. Accumulating evidence suggests that the cyclooxygenase-2 (COX-2)-specific inhibitor celecoxib would not only inhibit COX-2 but also help in the reversal of drug resistance in cancers by inhibiting the MDR1 efflux pump. Here, we demonstrate that celecoxib increases the sensitivity of bacteria to the...

Multidrug resistant (MDR) bacteria are spread through the world which causes nosocomial infections, especially in Intensive Care Unit (ICU). This study aimed to investigate resistance pattern of Pseudomonas aeruginosa and Enterobacter cloacae isolated from patients in ICU. During 2011-2012, 30 isolates for each P. aeruginosa and E. cloacae were collected from patients who acquired nosocomial in...

A multidrug-resistant (MDR) Escherichia coli strain from a human-associated pulsotype within sequence type ST131 (O25:H4) colonized three of five dogs and cats within a household. Of the four other colonizing strains identified, two were MDR and two colonized multiple hosts. The ST131 strain uniquely exhibited high resistance and virulence scores.